滋肾养巢方治疗肾阴虚型绝经前后诸证的临床研究

发布时间：2018-05-31 18:35

本文选题：绝经前后诸证 + 肾阴虚　；参考：《福建中医药大学》2016年硕士论文

【摘要】：目的：通过观察滋肾养巢方治疗肾阴虚型绝经前后诸证患者的临床疗效,以期寻求治疗肾阴虚型绝经前后诸证患者的良好的治疗方法。方法：将60例肾阴虚型绝经前后诸证的患者随机分为治疗组、对照组,每组各30例。其中治疗组以口服中药“滋肾养巢方”(导师经验方)为基础方,并可随症加减,于就诊当日开始服用,1剂／d,早晚分服,以连续服用12周为一个疗程；对照组口服替勃龙片(又名：紫竹爱维)2.50mg(1片),于就诊当日开始服用,每天固定同一时间服1次,以连续服用12周为一个疗程。两组均于治疗前采集改良Kupperman评分量表、肾阴虚证中医证候评分标准表、血清FSH、E2,且两组均于治疗12周后、停药4周后分别采集改良Kupperman评分量表、肾阴虚证中医证候评分标准表。观察治疗组及对照组在治疗12周后的临床疗效以及停药4周后的临床疗效维持情况。结果：1.滋肾养巢方及替勃龙均能改善肾阴虚型绝经前后诸证患者的临床症状,明显降低患者的改良Kupperman评分量表(P0.05)及肾阴虚型中医证候评分标准表(P0.05)。2.停药4周后两组的K评分差异有统计学意义(P0.05),停药4周后两组中医证候评分差异有统计学意义(P0.05)。3.治疗组在运用滋肾养巢方治疗肾阴虚型绝经前后诸证患者12周后的总有效率为93%,对照组在运用替勃龙治疗肾阴虚型绝经前后诸证患者12周后的总有效率为96.7%,经过统计学的分析,治疗组与对照组组间的差异无统计学意义(P0.05)。4.治疗组在停药4周后的总有效率为73.3%,对照组在停药4周后的总有效率为23.3%,两组组间的差异有统计学意义(P0.05)。结论：1.运用滋肾养巢方及替勃龙均能有效的治疗肾阴虚型绝经前后诸证患者,并且二者的近期临床疗效相当。2.滋肾养巢方在停药后的临床疗效维持方面优于替勃龙。
[Abstract]:Objective: to observe the clinical effect of Zishen Yangchao recipe in treating the patients with kidney yin deficiency before and after menopause, in order to seek a good treatment method for the patients with kidney yin deficiency before and after menopause. Methods: 60 cases of kidney yin deficiency before and after menopause were randomly divided into treatment group and control group with 30 cases in each group. Among them, the treatment group took "Zishen Yangcai recipe" (tutor's experience prescription) as the basic prescription, and could be added or subtracted with the symptom. On the same day, the treatment group began to take 1 dose / d, taking it separately in the morning and evening, and taking it continuously for 12 weeks as a course of treatment. The control group was given tibolone tablets (also known as Zizhu Avignon 2.50 mg / L) on the day of treatment, taking it at the same time every day for 12 weeks as a course of treatment. Both groups collected the modified Kupperman scale before treatment, the scale of TCM syndromes of kidney-yin deficiency syndrome and the serum FSHE2. After 12 weeks of treatment, the two groups collected the modified Kupperman scale after 12 weeks of treatment, and the traditional Chinese medicine syndromes scale of kidney-yin deficiency syndrome. To observe the clinical effect of treatment group and control group after 12 weeks and the maintenance of clinical effect after 4 weeks. The result is 1: 1. Both Zishenyangchaofang and Tibolong could improve the clinical symptoms of patients with kidney yin deficiency before and after menopause, and significantly reduce the modified Kupperman scale (P0.05) and the scale of TCM syndromes of kidney-yin deficiency (P0.05J. 2). After 4 weeks of withdrawal, the difference of K score between the two groups was statistically significant (P 0.05), and the difference of TCM syndrome score between the two groups after 4 weeks of withdrawal was statistically significant (P 0.05). 3. The total effective rate of the treatment group was 933 after 12 weeks after the treatment of kidney yin deficiency menopause with Zishen Yangchao recipe, and the total effective rate of the control group was 96. 7% after 12 weeks of treatment of the kidney yin deficiency menopause. There was no significant difference between the treatment group and the control group (P 0.05. 4). The total effective rate was 73.3 in the treatment group and 23.3in the control group after 4 weeks. The difference between the two groups was statistically significant (P 0.05). Conclusion 1. Both Zishenyangchao recipe and tibolone can effectively treat the patients with kidney yin deficiency before and after menopause, and the short-term clinical efficacy of both is equivalent. 2. Zishen Yangcai recipe was superior to Tiblong in the maintenance of clinical efficacy after withdrawal of the drug.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.116

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