中医药治疗血小板聚集用药规律分析

发布时间：2018-05-31 18:38

本文选题：中医药 + 血小板聚集　；参考：《辽宁中医杂志》2017年05期

【摘要】：通过对国家专利网、知网数据库搜索、筛选出关于抗血小板聚集的中成药及中药方剂组方共有164首,并录入中医传承辅助系统(V1.1),采用软件集成的改进互信息法、复杂系统熵聚类、无监督的熵层次聚类等无监督数据挖掘方法,分析抗血小板聚集的中成药及中药方剂组方规律。其中,用药频次大于10的有22味中药,排在前五位的是川芎(67)、黄芪(45)、当归(45)、丹参(44)、红花(43)、三七(31),设置支持度个数为10及置信度0.6时,得出排前三位的药对频次为川芎、当归(32)、川芎、红花(28)、当归、红花(23),可以看出治疗血小板聚集主要以活血化瘀、理(益)气通络为主,及兼以补肾、健脾药,并能演化得到核心组合53个,新处方7个,这为临床治疗血小板聚集及开发抗血小板药物提供用药参考。
[Abstract]:Through searching the national patent network and the database of knowledge network, 164 prescriptions of Chinese patent medicine and traditional Chinese medicine prescriptions for anti-platelet aggregation were selected, and the Chinese medicine heritage assistant system (V1.1) was inputted, and the improved mutual information method of software integration was adopted. Unsupervised data mining methods such as complex system entropy clustering and unsupervised entropy hierarchical clustering were used to analyze the prescription of traditional Chinese medicine and traditional Chinese medicine for anti-platelet aggregation. Among them, 22 herbs were used more frequently than 10, and the top five were Chuanxiong 67, Astragalus, Rhizoma Chuanxiong, Radix angelicae Sinensis, Radix Salviae Miltiorrhizae, Salvia miltiorrhiza, Radix Notoginseng and Radix Notoginseng, when the number of support was 10 and the confidence was 0.6, it was concluded that the first three drug pairs were Chuanxiong. It can be seen that the main treatment of platelet aggregation is promoting blood circulation, removing blood stasis, regulating qi and dredging collaterals, as well as tonifying the kidney, strengthening spleen, and evolving 53 core combinations and 7 new prescriptions. This provides a reference for clinical treatment of platelet aggregation and development of antiplatelet drugs.
【作者单位】：天津中医药大学天津市现代中药重点实验室;
【基金】：国家重点基础研究发展计划(“973”计划)资助项目(2012CB518404)
【分类号】：R259

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