补肾活血汤治疗肾虚肝郁型卵巢功能减退的临床研究
本文选题：补肾活血汤 + 卵巢功能减退 ； 参考：《南京中医药大学》2017年硕士论文
【摘要】：目的:通过研究补肾活血汤治疗肾虚肝郁型卵巢功能减退患者的临床疗效,阐明补肾活血汤对肾虚肝郁型卵巢功能减退的预防、治疗作用,为临床中医药治疗卵巢功能减退提供理论依据。方法:收集2016年4月1日-2017年3月1日在江苏省中西医结合医院妇科门诊就诊的41例辩证属于肾虚肝郁型卵巢功能减退患者,随机分为治疗组21例和对照组20例。治疗组予补肾活血汤治疗,对照组予激素替代治疗,治疗3月后观察两组治疗前后的临床症状,血清性激素的变化,AFC,OVD及RI的变化,并且观察两组间的差异。结果:1.治疗组综合临床疗效为76%,对照组综合临床疗效为70%,两组间统计无显著差异(P0.05)。治疗组中医症候总有效率为81%,对照组中医证候总有效率为75%,两组组间统计无显著差异(P0.05),两组治疗后与治疗前均有显著差异(P0.05)。治疗组和对照组均能改善卵巢功能减退患者月经不调与肾虚肝郁的临床症状。2.两组治疗后FSH,FSH/LH水平下降、E2水平上升,与治疗前均有显著差异(P0.05);治疗组LH水平下降,与治疗前相比有显著差异(P0.05),对照组LH水平有所下降,但与治疗前无显著差异(P0.05);治疗后两组组间LH、FSH比较有显著差异(P0.05),E2,FSH/LH 无显著差异(P0.05)。3.治疗组和对照组AFC治疗前后均有显著差异(P0.05),OVD、RI治疗前后均无显著差异(P0.05);治疗后两组组间AFC、RI比较有显著差异(P0.05),OVD比较无统计学意义(P0.05)。结论:1.补肾活血汤可改善肾虚肝郁卵巢功能减退患者月经不调等临床症状,在治疗腰膝酸软方面明显优于对照组;2.补肾活血汤能降低血清FSH、LH、FSH/LH,升高E2,升高AFC,调整下丘脑-垂体-卵巢轴,促进卵泡发育,改善卵巢血供,保护卵巢剩余组织,延缓卵巢功能衰退!
[Abstract]:Objective: to study the clinical effect of Bushen Huoxue decoction in treating ovarian dysfunction with kidney deficiency and liver depression, and to elucidate the preventive and therapeutic effects of Bushen Huoxue decoction on ovarian dysfunction due to kidney deficiency and liver depression. To provide a theoretical basis for the treatment of ovarian dysfunction with traditional Chinese medicine. Methods: from April 1, 2016 to March 1, 2017, 41 patients with ovarian dysfunction were randomly divided into treatment group (n = 21) and control group (n = 20). The treatment group was treated with Bushen Huoxue decoction and the control group was treated with hormone replacement therapy. After 3 months of treatment, the clinical symptoms, the changes of serum sex hormones and the changes of AFCU OVD and RI were observed, and the difference between the two groups was observed. The result is 1: 1. The comprehensive clinical curative effect of the treatment group was 76g and that of the control group was 70. There was no significant difference between the two groups (P 0.05). The total effective rate of TCM syndrome was 81 in the treatment group and 75 in the control group. There was no significant difference in statistics between the two groups (P 0.05). There was significant difference between the two groups after treatment and before treatment. Both the treatment group and the control group can improve the clinical symptoms of menstrual disorder and kidney deficiency and liver depression in patients with ovarian dysfunction. After treatment, the level of FSH / LH decreased and E2 level increased, and there was significant difference between the two groups in the level of LH, the level of LH in the treatment group was significantly lower than that in the control group, and the level of LH in the control group was lower than that in the control group, and the level of LH in the treatment group was significantly lower than that in the control group. However, there was no significant difference between the two groups before and after treatment (P 0.05), and there was no significant difference between the two groups (P 0.05). There were significant differences between the treatment group and the control group before and after AFC treatment. There was no significant difference between the two groups before and after treatment, and there was no significant difference between the two groups before and after treatment. There was no significant difference between the two groups before and after treatment (P 0.05), and there was no significant difference between the two groups before and after treatment (P 0.05). Conclusion 1. Bushen Huoxue decoction can improve the clinical symptoms such as irregular menstruation in patients with kidney deficiency and liver depression and ovarian dysfunction. It is superior to the control group in the treatment of waist and knee weakness. Bushen Huoxue decoction can reduce the serum FSHLH, increase E2, increase AFC, adjust hypothalamus-pituitary-ovary axis, promote follicular development, improve ovarian blood supply, protect ovarian surplus tissue, and delay the decline of ovarian function!
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9
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