补肾健脾法治疗少弱精子症临床有效性的Meta分析

发布时间：2018-06-01 20:18

本文选题：补肾健脾 + 少弱精子症　；参考：《中华生殖与避孕杂志》2017年01期

【摘要】：目的系统评价补肾健脾法治疗少弱精子症的临床疗效。方法检索相关期刊论文(CNKI)、维普资源系统(VIP)以及万方数据库,均从建库至2014年12月,收集数据库中有关补肾健脾法治疗少弱精子症的随机对照试验(RCT)。制定严格的文献纳入标准和排除标准及检索策略,并对纳入文献进行方法学质量评价,采用Revman5.3软件进行统计分析。结果纳入8个RCT,共838例,根据对照不同分为单纯补肾组和西药组,但经过仔细筛选后,其中2项研究组间样本量差异较大,故针对单纯补肾组做敏感性分析。Meta分析显示,补肾健脾组在提高精子浓度及a级精子百分率方面优于单纯补肾组及西药组(P0.05)。结论在提高精子浓度及a级精子百分率方面,健脾补肾法有优于单纯补肾法及西药治疗的趋势,但所纳入文献质量不高,部分数据差异性过大,且敏感性分析证实本研究结果稳定性不高,因此有待更为设计严谨、合理的RCT来证实补肾健脾法的临床疗效。
[Abstract]:Objective to evaluate the clinical effect of tonifying kidney and invigorating spleen on oligozoospermia. Methods Chinese periodical full-text database (CNKI, Weipu Resource system) and Wanfang database were searched. From the establishment of the database to December 2014, a randomized controlled trial of tonifying kidney and invigorating spleen in treating oligozoospermia was collected. Strict literature inclusion criteria, exclusion criteria and retrieval strategies were formulated, and the methodological quality of the included documents was evaluated, and the statistical analysis was carried out by using Revman5.3 software. Results eight RCTs were included in 838 cases. According to the control group, 838 cases were divided into simple kidney tonifying group and western medicine group. But after careful screening, there were significant differences in sample size between two study groups. Therefore, sensitivity analysis and meta analysis were done for the simple kidney tonifying group. The group of tonifying kidney and invigorating spleen was superior to the group of tonifying kidney and western medicine in improving the sperm concentration and the percentage of grade a spermatozoa. Conclusion the method of invigorating the spleen and tonifying the kidney is superior to the simple method of tonifying the kidney and the treatment of western medicine in improving the sperm concentration and the percentage of grade a spermatozoa, but the quality of the literature is not high, and the difference of some data is too great. Sensitivity analysis confirmed that the stability of the results of this study is not high, so it needs more rigorous design, reasonable RCT to verify the clinical efficacy of tonifying the kidney and invigorating the spleen.
【作者单位】：天津中医药大学第一附属医院;天津市中医药研究所附属医院;

【相似文献】