温阳解毒消瘿方治疗脾肾阳虚型桥本甲状腺炎的临床研究

发布时间：2018-06-05 07:58

本文选题：温阳解毒消瘿方 + 脾肾阳虚　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:本研究旨在通过观察以健脾疏肝、温阳解毒、消瘿散结为组方原则的温阳解毒消瘿方治疗脾肾阳虚型桥本甲状腺炎的临床疗效,客观评价其疗效及安全性,探讨其作用机制和治疗优势。方法:采用随机对照研究,选取脾肾阳虚型桥本甲状腺炎患者60例,随机分为治疗组、对照组各30例。治疗前两组均给予优甲乐,早餐前口服,剂量根据患者自身甲状腺激素情况调整,控制甲状腺激素在正常范围为止。治疗组在此基础上加用温阳解毒消瘿方,疗程均为12周,观察治疗前后两组患者临床症状、体征,血清甲状腺激素水平、血清甲状腺自身抗体滴度以及女性患者血清雌二醇水平的改变,对相关数据采用统计软件进行统计分析,评价其综合疗效。结果:对照组总有效率为89.5%,治疗组总有效率为58.3%。在改善桥本病各项症状、体征方面前后比较,治疗组明显优于对照组;在降低甲状腺抗体滴度方面前后比较,治疗组明显优于对照组;在改善女性患者血清雌二醇水平水平方面前后比较,治疗组明显优于对照组。经统计学统计,试验组未发现明显不良反应,安全性较高。结论:以健脾疏肝、温阳解毒、消瘿散结为组方原则的温阳解毒消瘿方可以明显改善脾肾阳虚型桥本甲状腺炎患者的临床症状、体征,改善甲状腺激素水平、甲状腺自身抗体水平与女性雌二醇水平,且无明显不良反应,是一种有效、安全的治疗方法,值得进一步开发利用。
[Abstract]:Objective: the purpose of this study was to observe the clinical effect of Wenyang jiedu Xiaoying recipe (WJXD) on treating Hashimoto thyroiditis with spleen and kidney yang deficiency by observing the principle of invigorating spleen and soothing liver, warming yang and detoxifying toxin, and eliminating gall dispersal, and to evaluate objectively its efficacy and safety. To explore its mechanism and therapeutic advantages. Methods: 60 cases of Hashimoto's thyroiditis with deficiency of spleen and kidney yang were randomly divided into treatment group (n = 30) and control group (n = 30). Before treatment, both groups were given metochlor, oral before breakfast, the dosage was adjusted according to the patients' own thyroid hormone, and the thyroid hormone was controlled in the normal range. The treatment group was treated with Wenyang jiedu Xiaoying recipe for 12 weeks. The clinical symptoms, signs and serum thyroid hormone levels were observed before and after treatment. The changes of serum thyroid autoantibody titer and serum estradiol level in female patients were evaluated by statistical software. Results: the total effective rate was 89. 5% in the control group and 58. 3% in the treatment group. In improving the symptoms and signs of Hashimoto's disease, the treatment group was obviously better than the control group, and the treatment group was obviously better than the control group in reducing thyroid antibody titer. The treatment group was better than the control group in improving the serum estradiol level of female patients. According to statistics, no obvious adverse reactions were found in the test group, and the safety was high. Conclusion: Wenyang jiedu Xiaoying prescription based on the principle of invigorating spleen and soothing liver, warming yang and detoxifying toxin, and eliminating gall dispersal can obviously improve the clinical symptoms and signs of Hashimoto's thyroiditis with deficiency of spleen and kidney yang, improve the level of thyroid hormone, and improve the level of thyroid hormone. Thyroid autoantibody level and female estradiol level, and no obvious adverse reactions, is an effective and safe treatment method, worthy of further development and utilization.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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