慢性肾衰竭合并高磷血症非透析患者的中医证候及相关因素研究

发布时间：2018-06-06 14:16

本文选题：慢性肾衰竭 + 高磷血症　；参考：《成都中医药大学》2016年硕士论文

【摘要】：目的：本研究旨在探索慢性肾衰竭合并高磷血症的非透析患者的中医证候分布情况,并研究其中医证型与实验室指标有无相关性,为慢性肾衰竭合并高磷血症的非透析患者提供客观中医辨证依据。方法：本研究以慢性肾衰竭合并高磷血症的非透析患者为研究对象,采用横断面调查的试验设计,收集132例患者一般情况,按照中医证候标准分为不同证型,同时收集血肌酐、血钙、血磷、估算肾小球滤过率、血红蛋白、血清白蛋白、促甲状旁腺激素等实验室检查结果,对慢性肾衰竭中医证型分布情况及中医证型与以上实验室结果的相关性进行统计学分析。结果：1.慢性肾衰竭合并高磷血症非透析患者中医证候分布以本虚证为主,本虚诸证中气虚证最多,占52.27%,其次是阴虚证、阳虚证,血虚证较少见；标实兼证以水湿证多见,占33.33%,其次是血瘀证、湿热证,溺毒证较少见,部分无兼证。2.随着肾功能的下降,慢性肾衰竭合并高磷血症非透析患者血磷水平呈升高趋势,当CKD达到4期后血磷水平出现明显升高。3.慢性肾衰竭合并高磷血症非透析患者不同本虚证型之间,血磷水平血虚证阴虚证阳虚证气虚证,但差异无统计学意义。4.慢性肾衰竭合并高磷血症非透析患者中血虚证的血肌酐、估算肾小球滤过率、血红蛋白、血钙都与其他证型有统计学差异,因此在临床辨证可将以上指标作为血虚证的参考指标。结论：慢性肾衰竭合并高磷血症非透析患者本虚诸证中气虚证最多见。慢性肾衰竭合并高磷血症非透析患者血虚证与血肌酐、估算肾小球滤过率、血红蛋白、血钙、甲状旁腺激素、血清白蛋白等实验室指标之间存在一定的相关性。
[Abstract]:Objective: to explore the distribution of TCM syndromes in non-dialysis patients with chronic renal failure and hyperphosphatemia, and to study the correlation between TCM syndromes and laboratory indexes. To provide objective TCM syndrome differentiation basis for non-dialysis patients with chronic renal failure and hyperphosphatemia. Methods: in this study, 132 patients with chronic renal failure complicated with hyperphosphatemia were divided into different syndromes, and blood creatinine was collected according to TCM syndrome standard, using a cross-sectional investigation of the experimental design, 132 patients were divided into different syndromes according to the criteria of TCM syndromes, and blood creatinine was collected at the same time. Blood calcium, blood phosphorus, estimated glomerular filtration rate, hemoglobin, serum albumin, parathyroid hormone and other laboratory results, The distribution of TCM syndromes of chronic renal failure (CRF) and the correlation between TCM syndromes and the above laboratory results were analyzed statistically. The result is 1: 1. In patients with chronic renal failure and hyperphosphatemia, the distribution of TCM syndromes was mainly based on the syndrome of deficiency of essence, the most of which was deficiency of qi (52.27), followed by deficiency of yin, deficiency of yang, and deficiency of blood. Accounted for 33. 33, followed by blood stasis syndrome, damp-heat syndrome, drug addiction syndrome is rare, some without a concurrent syndrome. 2. With the decline of renal function, the level of blood phosphorus in patients with chronic renal failure and hyperphosphatemia showed an increasing trend. When CKD reached 4 stages, the level of serum phosphorus increased significantly. 3. Chronic renal failure combined with hyperphosphatemia non-dialysis patients with different types of deficiency of blood phosphorus level of blood deficiency of yin and yang deficiency of qi syndrome, but the difference is not statistically significant. 4. The blood creatinine, glomerular filtration rate, hemoglobin and serum calcium in patients with chronic renal failure and hyperphosphatemia were significantly different from those of other syndrome types. Therefore, in clinical syndrome differentiation, the above indexes can be taken as the reference index of blood deficiency syndrome. Conclusion: deficiency of Qi syndrome is most common in patients with chronic renal failure and hyperphosphatemia. There was a certain correlation between blood deficiency and serum creatinine in patients with chronic renal failure and hyperphosphatemia, estimating glomerular filtration rate, hemoglobin, serum calcium, parathyroid hormone, serum albumin and other laboratory indexes.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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