半夏泻心汤治疗幽门螺杆菌相关性胃炎的疗效分析

发布时间：2018-06-06 15:59

本文选题：半夏泻心汤 + 幽门螺杆菌相关性胃炎　；参考：《临床医学研究与实践》2017年09期

【摘要】：目的观察半夏泻心汤治疗幽门螺杆菌相关性胃炎的疗效。方法收集2015年1月至2016年6月就诊于本科的幽门螺杆菌相关性胃炎患者120例,采用随机数字表法将符合纳入标准的患者随机分为两组,每组60例。对照组患者给予四联疗法治疗,试验组患者在四联疗法基础上加用半夏泻心汤加减,两组疗程均为2周,观察两组患者症状改善情况、幽门螺杆菌根除率、复发率、不良反应的发生率及安全性指标等。结果试验过程中两组各脱落1例,结果两组各收集病例59例。试验组治疗后,临床总有效率为96.62%,对照组为91.53%,两组总有效率比较,差异有统计学意义(P0.05)。随访半年,复查13C呼气试验,治疗组患者复发率为4.35%,对照组为33.33%,组间差异有统计学意义(P0.05)。服药过程中,试验组中出现头痛1例,恶心呕吐1例,不良反应的总发生率为3.38%,对照组患者出现头痛2例,腹泻2例,便秘3例,恶心呕吐2例,不良反应的总发生率为15.25%,两组不良反应总发生率比较,差异有统计学意义(P0.05)。两组患者治疗前后肝肾功能、尿常规、便常规、心电图等各项安全检查均未见异常改变。结论半夏泻心汤治疗幽门螺杆菌相关性胃炎患者,可明显提高幽门螺杆菌的根除率,降低不良反应的发生率,预防复发,值得在临床上广泛推广使用。
[Abstract]:Objective to observe the effect of Banxia Xiexin decoction on Helicobacter pylori associated gastritis. Methods 120 patients with Helicobacter pylori associated gastritis from January 2015 to June 2016 were randomly divided into two groups with 60 cases in each group. The patients in the control group were treated with quadruple therapy, and the patients in the experimental group were treated with Banxia Xiexin decoction on the basis of the quadruple therapy. The two groups were treated for 2 weeks. The improvement of symptoms, the eradication rate of Helicobacter pylori and the recurrence rate were observed in the two groups. The incidence and safety index of adverse reactions. Results one case was lost in each group, and 59 cases were collected in each group. After treatment, the total effective rate of the trial group was 96.62 and that of the control group was 91.53. The total effective rate of the two groups was significantly higher than that of the control group (P 0.05). After half a year follow-up and 13C breath test, the recurrence rate was 4.35 in the treatment group and 33.33 in the control group. The difference between the two groups was statistically significant (P 0.05). In the course of taking medicine, there were 1 headache and 1 nausea and vomiting in the trial group. The total incidence of adverse reactions was 3.38. In the control group, 2 patients had headache, 2 patients had diarrhea, 3 patients had constipation, 2 patients had nausea and vomiting. The total incidence of adverse reactions was 15.25%, and the difference between the two groups was statistically significant (P 0.05). There were no abnormal changes in liver and kidney function, urine routine, stool routine and electrocardiogram before and after treatment. Conclusion Banxia Xiexin decoction in the treatment of patients with Helicobacter pylori associated gastritis can obviously increase the eradication rate of Helicobacter pylori, reduce the incidence of adverse reactions, prevent recurrence, and be widely used in clinical practice.
【作者单位】：西安市高陵区崇皇中心卫生院;
【分类号】：R259

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