电针不同频次对围绝经期相关症状的缓解及血清性激素水平影响的随机对照研究

发布时间：2018-06-08 13:17

本文选题：电针 + 围绝经期综合征　；参考：《安徽中医药大学》2016年硕士论文

【摘要】：1目的通过观察电针不同频次的治疗对围绝经期综合征患者症状积分和性激素水平的改变情况,明确电针对围绝经期相关症状的治疗效应和频次的关系,初步探讨电针不同频次对围绝经期患者性激素水平的影响。2方法将符合本研究纳入、排除标准的患者30例按照1:1比例随机分为研究组和对照组,病例主要来源于安徽中医药大学第一附属医院针灸科、妇科门诊和安徽中医药大学国医堂门诊部针灸科。研究组和对照组采用相同的治疗操作方法和疗程,但研究组治疗频次为一周三次,对照组为一周一次。两组操作方法及疗程为:取穴关元、子宫双、天枢双、三阴交双,针刺后,双侧子宫和双侧天枢穴针柄分别横向连接电针仪导线(电针参数:疏密波,频率为10/50Hz,电流强度为0.5~1.0 m A),逐渐增大电流强度以患者腹部轻微颤动为度,留针30分钟,留针期间关元和三阴交穴行针3次,每10分钟1次;共治疗8周。两组均随访至32周结束。两组均在第0周、第4周、第8周、第20周和第32周5个时间点采用MRS量表对患者的症状进行评价,并在第0周、第8周和第20周3个时间点检测性激素。运用统计软件SPSS19.0进行统计分析,所有检验采用双侧检验,P0.05被认为具有统计学意义。3结果(1)研究组患者在治疗后第4周、第8周、第20周和第32周的MRS评分均有明显降低,差异具有显著性统计学意义(P0.01);对照组患者第4周、第8周的MRS评分有明显降低,差异有显著性统计学意义(P0.01),在第20周时MRS评分的降低差异有统计学意义(P0.05),第32周的MRS评分与基线期相比,差异无统计学意义(P0.05);治疗后两组第4周、第8周、第20周组间比较差异无统计学意义(P0.05),第32周组间比较差异有显著性统计学意义(P0.01)。(2)患者的FSH、LH、E2水平组内和组间比较差异均无统计学意义(P0.05)。(3)治疗8周后,研究组的总有效率为85.7%,对照组的总有效率为69.2%,两者比较差异无统计学意义(P0.05);治疗后第32周,研究组的总有效率为100%,对照组的总有效率为38%,两者比较差异有显著性统计学意义(P0.01);。4结论(1)电针能够有效缓解围绝经期相关症状,是临床治疗围绝经期综合征的有效方法。(2)针对围绝经期相关症状的电针治疗,一周三次和一周一次的治疗频次所产生的近期疗效无明显差异;一周三次的远期疗效优于一周一次。(3)电针对围绝经期综合征患者性激素水平的调整作用不明显。
[Abstract]:Objective to observe the changes of symptom score and sex hormone level in patients with peri-menopausal syndrome treated with electroacupuncture at different frequencies, and to clarify the relationship between the therapeutic effect and frequency of electroacupuncture on peri menopausal symptoms. Preliminary study on the effect of different frequency of electroacupuncture on sex hormone level in peri-menopausal patients. Methods 30 patients who met the criteria of exclusion were randomly divided into study group and control group according to the 1:1 ratio. The cases mainly come from the Department of Acupuncture and moxibustion of the first affiliated Hospital of Anhui University of traditional Chinese Medicine, the Department of Gynecology outpatient and the Department of Acupuncture and moxibustion of the outpatient Department of the The study group and the control group were treated with the same procedure and course of treatment, but the frequency of treatment was three times a week in the study group and once a week in the control group. The two groups of operation methods and course of treatment were as follows: acupoint Guan Yuan, uterus double, Sanyinjiao double, after acupuncture, bilateral uterus and bilateral Tianshu acupoint needle handle were transversely connected with electroacupuncture instrument wire (electroacupuncture parameter: density wave, electroacupuncture parameter: density wave), The frequency was 10 / 50 Hz, the current intensity was 0.5 ~ (1. 0) Ma ~ (-1), and the current intensity was gradually increased to the degree of slight fibrillation in the abdomen of the patient. The needle was kept for 30 minutes. During the period of keeping the needle, the points of Guan Yuan and Sanyinjiao were needled 3 times every 10 minutes, and the total treatment was 8 weeks. Both groups were followed up to the end of 32 weeks. The symptoms of the patients were evaluated by Mrs at 5 time points (0 week, 4 week, 8 week, 20 week and 32 week), and sex hormones were measured at 0, 8 and 20 weeks. Statistical software SPSS 19.0 was used to carry out statistical analysis. All the tests were carried out with bilateral test (P0.05). The scores of Mrs were significantly decreased in the study group at the 4th, 8th, 20th and 32nd week after treatment. The difference was statistically significant (P 0.01), and the Mrs scores in the control group were significantly lower than those in the control group at the 4th week and the 8th week. The difference was statistically significant (P 0.01), and the decrease of Mrs score was statistically significant at the 20th week (P 0.05), but there was no significant difference between the 32 week and the baseline period (P 0.05), the fourth week, the eighth week after treatment, the difference between the two groups was not statistically significant (P 0.05), and there was no significant difference between the two groups at the 4th week and the 8th week after treatment. There was no significant difference between the two groups at the 20th week (P 0.05), but there was significant difference between the groups at week 32 (P 0.01). There was no significant difference in the level of FSHLHN E 2 in the group and between the two groups after 8 weeks of treatment, and there was no significant difference between the two groups after 8 weeks of treatment, there was no significant difference in the level of FSHLHN E2 between the two groups after 8 weeks of treatment, there was no significant difference between the two groups. The total effective rate was 85.7 in the study group and 69.2 in the control group. There was no significant difference between the two groups (P 0.05). The total effective rate of the study group was 100 and the total effective rate of the control group was 38. There was a significant difference between the two groups. It is an effective method for clinical treatment of peri-menopausal syndrome. (2) electroacupuncture treatment for peri-menopausal symptoms has no significant difference between the frequency of treatment three times a week and the frequency of treatment once a week. The long-term effect of three times a week is better than that of once a week.) the effect of electroacupuncture on sex hormone level in patients with perimenopausal syndrome is not obvious.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.3

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