中药促进宫颈柱状上皮异位物理治疗后创面修复的临床观察及基于AQP2的机制探讨

发布时间：2018-06-08 19:58

本文选题：宫颈柱状上皮异位 + 物理治疗　；参考：《时珍国医国药》2017年07期

【摘要】：目的观察我院国家级名老中医易修珍经验方——固气利湿汤对宫颈柱状上皮异位患者经物理治疗后创面修复的临床疗效,并且从AQP2角度探讨中药起效的作用机制。方法 62例中重度宫颈柱状上皮异位患者,随机分为对照组(n=30)和治疗组(n=32)。均给予物理治疗的方法,对照组术后给予奥硝唑500mg bid口服1周预防感染,治疗组除外奥硝唑预防感染之外,同时给予中药固气利湿汤口服日一剂,持续2周。术后每2周随访一次,记录患者阴道排液持续时间、阴道排液量、阴道出血时间、创面愈合时间,同时观察术后的不良反应。两组治疗前均于阴道镜下取宫颈异位柱状上皮部位的组织活检,术后2周宫颈鳞柱交界处取材少量,测定AQP2蛋白表达量,探讨中药发挥作用的机制。结果两组患者基本资料比较,未见统计学差异(P0.05)。治疗组的阴道排液持续时间、阴道排液量、创面愈合时间,均显著低于对照组(P0.05),阴道出血时间未见差异(P0.05)。总的治疗效果,治疗组优于对照组(P0.05)。治疗后AQP2蛋白表达量,治疗组显著低于对照组(P0.05)。结论宫颈柱状上皮异位患者给予物理治疗是一种安全有效的治疗方法,术后给予中药固气利湿汤治疗,可显著降低患者术后阴道排液量、阴道排液时间,促进创面的愈合,提高治疗效果。减少阴道排液的作用机制可能与下调AQP2蛋白有关系。
[Abstract]:Objective to observe the clinical curative effect of Yi Xiuzhen experience decoction (GQLSD), a national famous traditional Chinese medicine, on wound repair of patients with cervical columnar epithelial ectopic after physical therapy, and to explore the mechanism of the effect of traditional Chinese medicine from AQP2 point of view. Methods Sixty-two patients with moderate and severe ectopic cervical columnar epithelium were randomly divided into control group (n = 30) and treatment group (n = 32). The control group was given ornidazole 500mg bid for 1 week to prevent infection, the treatment group except ornidazole for preventing infection, and the treatment group for 2 weeks. The patients were followed up every 2 weeks to record the duration of vaginal effusion, the amount of vaginal effusion, the time of vaginal bleeding, the time of wound healing, and the adverse reactions after operation. Tissue biopsy of cervical ectopic columnar epithelium was performed under colposcopy in both groups before treatment. A small amount of samples were obtained at the junction of cervical squamous column 2 weeks after operation to determine the expression of AQP2 protein and to explore the mechanism of Chinese medicine acting on it. Results there was no statistical difference between the two groups (P 0.05). The duration of vaginal effusion, the amount of vaginal effusion and the healing time of wound in the treatment group were significantly lower than those in the control group (P 0.05). There was no difference in vaginal bleeding time between the two groups (P 0.05). The total therapeutic effect of the treatment group was better than that of the control group (P 0.05). After treatment, the expression of AQP2 protein in the treatment group was significantly lower than that in the control group (P 0.05). Conclusion physical therapy is a safe and effective method for patients with cervical columnar epithelium ectopic. After operation, the treatment with Gushi Lishi decoction can significantly reduce the amount of vaginal efflux, the time of vaginal drainage, and promote the wound healing. Improve the therapeutic effect. The mechanism of reducing vaginal effusion may be related to the down-regulation of AQP2 protein.
【作者单位】：云南省中医医院;云南中医学院;
【基金】：云南省卫生科技计划项目(No.2014NS303)
【分类号】：R271.9

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