芪竹参草汤治疗慢性萎缩性胃炎癌前病变的临床研究

发布时间：2018-06-11 19:56

本文选题：芪竹参草汤 + 慢性萎缩性胃炎　；参考：《南京中医药大学》2016年硕士论文

【摘要】：目的探讨芪竹参草汤治疗慢性萎缩性胃炎癌前病变的临床疗效及其作用机理。方法选取符合纳入标准的CAG痈前病变患者60例,并将其随机分为治疗组及对照组各30例。治疗组予芪竹参草汤方加减治疗,每口一剂,水煎服2次,每次煎200m1,每日2次；对照组予胃复春片治疗,每几3次,每次4片。两组均以3个月为一疗程,服药2个疗程。观察并记录两组治疗前后中医症状和病理积分,并对两组临床症状、胃镜征象及黏膜炎症、萎缩、肠化、异型增生等病理疗效进行比较。结果两组临床症状均有所改善,治疗组临床有效率为86.7%,对照组73.3%,比较有统计学意义(P0.05)；在对胃镜征象、炎症、萎缩、肠化方面的改善,治疗组有效率分别为83.3%、76.7%、86.7%、83.3%；对照组分别为70.0%、53.3%、56.7%、53.3%,治疗组优于对照组,比较有统计学意义(P0.05)；治疗组异型增生有效率50.0%,对照组为33.4%,差异无统计学意义(P0.05)。两组治疗期间均未发生不良反应。结论通过相关数据分析,治疗组在改善临床症状、胃镜征象及病理表现上均优于对照组。说明芪竹参草汤是治疗CAG癌前病变的有效方药,具有显著的临床疗效,能缓解甚至解除病患的临床症状,减轻腺体炎症及萎缩,促进病变胃黏膜的修复,从而提高患者的生活质量。
[Abstract]:Objective to explore the clinical effect and mechanism of qqh Shen Cao Decoction in the treatment of precancerous lesions of chronic atrophic gastritis. Methods 60 patients with CAG precancerous lesions were selected and divided into treatment group and control group (30 cases each). The treatment group was treated with Qi Zhu Shen Cao decoction, one dose per mouth, 2 times of decoction, each decocting 200m1, each time. 2 times a day, the control group was treated with Wei Fu Chun tablets, every few 3 times, 4 tablets each time. Two groups were treated with 3 months as a course of treatment and 2 courses of medicine. Observe and record the symptoms and pathological scores of traditional Chinese medicine before and after treatment of two groups, and compare the pathological effects of two groups of clinical symptoms, gastroscope and mucous inflammation, atrophy, intestinal metaplasia and dysplasia. The clinical effective rate of the treatment group was 86.7%, the control group was 73.3%, with statistical significance (P0.05). The improvement of the gastroscopy, inflammation, atrophy and intestinal metaplasia in the treatment group was 83.3%, 76.7%, 86.7%, 83.3% respectively, and the control group was 70%, 53.3%, 56.7%, 53.3% respectively, and the treatment group was better than the control group, and the comparison was statistically significant. The comparison was statistically significant. Significance (P0.05), the effective rate of dysplasia in the treatment group was 50%, the control group was 33.4%, the difference was not statistically significant (P0.05). The two groups did not have adverse reactions during the treatment. Conclusion through the analysis of the related data, the treatment group is better than the control group in improving the clinical symptoms, the gastroscope and the pathological manifestations. It shows that the Qi Zhu Shen grass soup is the treatment of CAG precancerous disease. The effective prescription has significant clinical efficacy, relieves or even relieves the clinical symptoms of the patients, reduces gland inflammation and atrophy, promotes the repair of the pathological gastric mucosa, and thus improves the quality of life of the patients.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】