中医联合疗法治疗中度溃疡性结肠炎的临床研究

发布时间：2018-06-11 21:40

本文选题：健脾渗湿止血方 + 中医联合疗法　；参考：《河北医科大学》2016年硕士论文

【摘要】：据资料显示,目前市场上治疗溃疡性结肠炎(UC)的灌肠制剂较少,特别是纯中药的制剂更少,西药多以抗生素加激素等灌肠,效果不确切,与中药相比副作用较大,远期效果不确定。本研究采用“健脾渗湿止血方”(木香10g、诃子10g、茯苓10g、白术10g、白芍10g、甘草6g、山药20g、当归10g、仙鹤草30g、薏苡仁30g、马齿苋30g、槐角10g、地榆炭15g、延胡索10g、白头翁30g、槟榔12g、升麻6g)口服、保留灌肠及耳穴贴压对UC进行治疗,旨在观察中医联合疗法治疗中度溃疡性结肠炎的临床疗效。目的:对“健脾渗湿止血方”口服、保留灌肠及耳穴贴压治疗中度溃疡性结肠炎的临床疗效进行评估。方法:依据就诊顺序,按照随机数字表纳入40例患者,随机单盲,分为治疗组和对照组。治疗组予以“健脾渗湿止血方”口服、保留灌肠及耳穴贴压进行治疗,对照组服用常规美沙拉嗪片加甲硝唑葡萄糖和庆大霉素进行治疗。观察记录治疗前后两组患者的临床症状、体征、中医症候及安全性指标。结果:研究结果表明治疗组和对照组患者的活动性评分、中医症候疗效和临床疗效等观察指标在治疗后均得到显著改善,表明“健脾渗湿止血方”口服、保留灌肠及耳穴贴压中医联合疗法和传统的美沙拉嗪疗法均对溃疡性结肠炎有一定的疗效。1.比较治疗3个月的观察指标,结果表明治疗组患者的活动性评分、中医症候疗效和临床疗效与对照组均无明显差异,说明两组治疗方案的短期治疗效果无统计学差异。2.对比治疗6个月后的观察指标,结果表明治疗组患者的活动性评分、中医症候疗效和临床疗效均明显优于对照组。结论:“健脾渗湿止血方”口服、保留灌肠及耳穴贴压中医联合疗法对治疗中度溃疡性结肠炎具有良好的临床疗效,具有推广价值。
[Abstract]:According to the data, there are fewer enema preparations for the treatment of ulcerative colitis on the market at present, especially the preparation of pure Chinese medicine, and the western medicine is mostly enema with antibiotics and hormones, the effect is not exact, and the side effect is greater than that of traditional Chinese medicine. The long-term effect is uncertain. In this study, "invigorating spleen and oozing dampness and hemostatic prescription" (10 g of wood incense, 10g of chebula, 10g of Poria cocos, 10g of Atractylodes macrocephala, 10g of Paeoniae Alba, 6g of licorice, 20g of yam, 10g of Angelica sinensis, 30g of purslane, 10g of locust angle, 15g of elm charcoal, 10g of Yanhusuo, 30g of Weng Weng, 12g of betel nut, 6g of Shengma) were taken orally. Retention enema and auricular plaster were used to treat UC in order to observe the clinical effect of TCM combined therapy on moderate ulcerative colitis. Objective: to evaluate the clinical effect of "Jianpi Yizhi Zhixue recipe" in treating moderate ulcerative colitis by oral administration, retention enema and ear point plaster. Methods: according to the order of visit, 40 patients were randomly divided into treatment group and control group. The treatment group was treated by oral administration of "Jianpi Yizhi Zhixue recipe", retention enema and auricular point pressing, while the control group was treated with Metronidazole, glucose and gentamicin. The clinical symptoms, signs, TCM symptoms and safety indexes of the two groups were recorded before and after treatment. Results: the results showed that the activity score, the curative effect of traditional Chinese medicine and the clinical curative effect of the patients in the treatment group and the control group were significantly improved after the treatment, indicating that "Jianpi Yizhi Zhixue prescription" was taken orally. Both retention enema and auricular plaster therapy combined with traditional meralazine therapy have a certain curative effect on ulcerative colitis. 1. The results showed that there was no significant difference in activity score, TCM symptom efficacy and clinical efficacy between the two groups and the control group, indicating that there was no significant difference in short-term therapeutic effect between the two groups. 2. The results showed that the activity score, the curative effect of TCM symptom and the clinical effect of the treatment group were better than those of the control group. Conclusion: the traditional Chinese medicine combination therapy of "invigorating spleen and oozing dampness and stopping bleeding", retention enema and ear point plaster has good clinical effect on treating moderate ulcerative colitis, and it is worth popularizing.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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