益肾清利方对慢性肾炎肾虚湿热证患者TNF-α、IL-6、IL-10影响的研究

发布时间：2018-06-14 07:38

本文选题：慢性肾炎 + 益肾清利　；参考：《辽宁中医杂志》2017年05期

【摘要】：目的:观察益肾清利方对慢性肾炎肾虚湿热证患者临床疗效及调控血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)的作用。方法:60例慢性肾炎肾虚湿热证患者分为治疗组和对照组各30例。治疗组使用西医基础治疗配合中药益肾清利方,对照组仅给予西医基础治疗,疗程1个月。采用双抗体夹心ELISA法测定患者治疗前后血清TNF-α、IL-6、IL-10水平。结果:益肾清利方联合西医基础治疗在提高临床疗效,降低尿蛋白、血尿方面明显优于单用西医基础治疗,特别针对尿红细胞计数改善与对照组相比,具有显著优势。治疗后两组TNF-α、IL-6水平均较治疗前下降,治疗组较对照组下降更为明显(P0.05);治疗组治疗后IL-10水平较前升高(P0.05),而对照组治疗前后无差异(P0.05)。结论:益肾清利方对TNF-α、IL-6、IL-10的调节作用,可能是其治疗慢性肾炎肾虚湿热证患者的作用机理之一。
[Abstract]:Objective: to observe the effect of Yishen Qingli recipe on chronic nephritis with deficiency of kidney dampness and heat syndrome and the effect of regulating serum TNF- 伪, interleukin-6, interleukin-10 (IL-10). Methods 60 patients with chronic nephritis were divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with western medicine combined with Yishen Qingli prescription, while the control group was only treated with western medicine for one month. The serum levels of TNF- 伪 IL-6 and IL-10 were measured by double antibody sandwich Elisa before and after treatment. Results: Yishen Qingli prescription combined with Western medicine basic treatment in improving the clinical efficacy, reducing urine protein, hematuria is significantly better than the Western basic treatment alone, especially for the improvement of urine red blood cell count compared with the control group, has a significant advantage. After treatment, the levels of TNF- 伪 and IL-6 in both groups were lower than those before treatment, and the levels of IL-10 in the treatment group were significantly lower than those in the control group (P 0.05), while the level of IL-10 in the treatment group was higher than that before and after treatment, but there was no difference in the control group before and after treatment. Conclusion: the regulating effect of Yishen Qingli recipe on IL-10 of TNF- 伪 and IL-6 may be one of the mechanisms of Yishen Qingli recipe in the treatment of chronic nephritis with dampness and heat syndrome.
【作者单位】：南京市中医院;
【基金】：江苏省中医药局资助项目(LZ13101)
【分类号】：R277.5

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