通络止痛方治疗风痰阻络型紧张性头痛的临床研究

发布时间：2018-06-14 17:28

本文选题：紧张性头痛 + 风痰阻络　；参考：《北京中医药大学》2017年硕士论文

【摘要】：全球疾病监测机构认为,紧张性头痛为全球第二流行疾病。现今社会,人们对生活质量的追求越来越高。紧张性头痛影响人的行为能力、工作、学习和日常休闲,严重降低了人们生活的质量。目前西医对紧张性头痛尚无特效疗法,但大量文献及临床研究为中医药治疗紧张性头痛提供了重要的循证依据,因此,加强中医方面对紧张性头痛的研究是必要的。本研究目的:观察通络止痛方对风痰阻络型紧张性头痛患者头痛程度、发作频率、持续时间、伴随症状、止痛药暴露等指标的临床改善疗效,为临床应用提供初步的科学依据。方法:选取符合纳入标准的风痰阻络型紧张性头痛患者34例,按照门诊就诊顺序入组后,服用通络止痛方3个疗程,随访3个月,分别选取第1疗程、第2疗程、第3疗程、随访第3个月的最后1周对比基线入组前1周,观察其头痛程度评分、头痛发作频率、头痛发作持续时间、伴随症状、止痛药暴露情况等指标的变化及通络止痛方3个月的长期维持效果。同时观察用药期间药物的不良反应和副作用,对治疗结果进行疗效评定,并对相关数据采用SPSS21统计软件进行统计分析。结果:1.第1疗程、第2疗程、第3疗程、第3个月与治疗前相比,VAS评分、疼痛持续时间、伴随症状评分均P值0.05,提示患者疼痛程度、疼痛持续时间、伴随症状评分指标在第1疗程、第2疗程、第3疗程、第3个月与治疗前相比均有改善。2.第1疗程、第2疗程、第3疗程、第3个月与治疗前相比,患者疼痛发作频率P值0.05,提示患者头部疼痛发作频率第1疗程、第2疗程、第3疗程、第3个月与治疗前相比均有疗效。3.第1疗程、第2疗程、第3疗程、第3个月与治疗前相比,患者止痛药暴露情况P值0.05,提示患者止痛药暴露情况第1疗程、第2疗程、第3疗程、第3个月与治疗前相比均有疗效。结论:通络止痛方治疗风痰阻络型紧张性头痛有临床疗效,可减轻患者发作时头痛程度,降低头痛发作频率,缩短头痛持续时间,改善伴随症状,减少止痛药服用次数,并具有3个月的长期维持效果,可作为风痰阻络型紧张性头痛发作期及预防性治疗的有效治疗方法,值得进一步的深入研究。
[Abstract]:The global disease surveillance agency believes that tension headache is the second most prevalent disease in the world. Nowadays, people's pursuit of quality of life is getting higher and higher. Tension headache affects people's behavior, work, study and daily leisure, and seriously reduces the quality of life. At present, there is no effective therapy for tension headache in western medicine, but a large number of literatures and clinical studies have provided an important evidence-based basis for the treatment of tension headache by traditional Chinese medicine. Therefore, it is necessary to strengthen the research on tension headache in traditional Chinese medicine. Objective: to observe the clinical improvement effect of Tongluo Zhitong recipe on headache degree, attack frequency, duration, accompanying symptoms and analgesic exposure in patients with tension headache of wind-phlegm blocking collaterals type, and to provide a preliminary scientific basis for clinical application. Methods: 34 patients with tension headache of wind-phlegm blocking collaterals type were selected. According to the order of outpatient visit, the patients were treated with Tongluo Zhitong recipe for 3 courses, followed up for 3 months, and the first course, the second course, the third course of treatment, respectively, were selected. The last week of the third month of follow-up was compared with the first week before baseline entry. The score of headache severity, the frequency of headache attack, the duration of headache attack, and the accompanying symptoms were observed. Changes of painkillers exposure and long-term maintenance effect of Tongluo Zhitong prescription for 3 months. At the same time, the adverse reactions and side effects of the drugs were observed and the therapeutic effects were evaluated. The related data were analyzed by SPSS21 software. The result is 1: 1. The scores of VAS, duration of pain and accompanying symptoms were 0.05 in the first course, the second course, the third month compared with those before treatment, indicating the degree of pain, the duration of pain, and the score of accompanying symptoms in the first course of treatment. The second course of treatment, the third month compared with the treatment before the improvement. 2. The first course, the second course, the third month compared with before treatment, the patient pain attack frequency P value 0.05, indicated the patient head pain attack frequency the first course, the second course of treatment, the third course, the third course of treatment, the first course of treatment, the second course of treatment, the third course of treatment, The third month compared with the treatment before treatment. 3. 3. The first course of treatment, the second course of treatment, the third month compared with before treatment, the patient painkiller exposure P value 0.05, indicating the patient's painkillers exposure the first course, the second course of treatment, the third course of treatment, The third month was effective compared with that before treatment. Conclusion: Tongluo Zhitong recipe has clinical effect in treating tension headache of wind-phlegm blocking collaterals type. It can reduce the degree of headache, reduce the frequency of headache attack, shorten the duration of headache, improve the accompanying symptoms, and reduce the times of taking painkillers. It can be used as an effective treatment method for wind-phlegm blocking collateral-type tension headache attack and preventive treatment, which is worthy of further study.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.7

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