脑血疏口服液对脑出血大鼠血肿体积及神经功能的影响

发布时间：2018-06-15 04:13

本文选题：脑血疏口服液 + 脑出血　；参考：《中国老年学杂志》2017年01期

【摘要】：目的探讨脑血疏口服液对脑出血(ICH)模型大鼠血肿体积及神经功能的影响。方法 77只雄性SD大鼠,随机分为ICH对照组(n=35)、ICH实验组(n=35)及假手术组(n=7),ICH对照组和实验组使用Ⅳ型胶原酶造模,术后12 h给予ICH实验组脑血疏口服液灌胃1 ml/kg,其他两组给予同等剂量的生理盐水灌胃。治疗后将ICH对照组和实验组分为1、2、4、7、14 d 5个亚组,每组7只,采用Longa法对两组不同时间的神经功能进行评估,并测量脑血肿体积的变化。结果治疗后7 d和14 d,ICH实验组大鼠Longa评分显著低于ICH对照组(均P0.05),治疗后4~14 d ICH实验组大鼠血肿体积显著小于ICH对照组(均P0.05)。结论脑血疏口服液治疗ICH大鼠疗效确切,能显著促进血肿的吸收,恢复大鼠神经功能。
[Abstract]:Objective to study the effect of Naoxue Shu oral liquid on hematoma volume and nerve function in ICH rats. Methods Seventy-seven male Sprague-Dawley rats were randomly divided into ICH control group (ICH control group) and sham operation group (ICH control group and experimental group). ICH group was given 1 ml / kg Naoxue Shu oral liquid 12 hours after operation, and the other two groups were given the same dose of normal saline. After treatment, the ICH control group and the experimental group were divided into 5 subgroups for 14 days, 7 rats in each group. The neurological function of the two groups was evaluated by Longa method and the changes of hematoma volume were measured. Results the Longa score of ICH experimental group was significantly lower than that of ICH control group on the 7th and 14th day after treatment (all P 0.05), and the hematoma volume of ICH experimental group was significantly smaller than that of ICH control group on the 14th day after treatment (all P 0.05). Conclusion Naoxue Shu oral liquid is effective in the treatment of ICH rats. It can significantly promote the absorption of hematoma and restore the nerve function of rats.
【作者单位】：河南省中医院脑病科;河南省中医院中心试验室;
【分类号】：R277.7

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