解毒活血方治疗瘀毒互结型IgA肾病的临床研究

发布时间：2018-06-17 06:39

本文选题：解毒活血方 + IgA肾病　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察解毒活血方治疗瘀毒互结型IgA肾病的临床疗效,以期充分发挥祖国传统医学优势,提高本病的治疗水平,改善患者生活质量。方法:将收集到的瘀毒互结型IgA肾病患者60例,随机分为治疗组30例、对照组30例。对照组给予抗感染、抗凝、降压、调脂等西医对症治疗,治疗组在西医对症治疗的基础上加用解毒活血方,4周为1个疗程,2个疗程后观察患者尿红细胞计数、24h尿蛋白定量、血肌酐、尿素氮的变化,并对症状及体征进行量化评分,判定其疗效。结果:中医量化评分中,治疗组总有效率为83.3%,对照组总有效率为60.0%,治疗组总有效率高于对照组(P0.01)。治疗组各症状较治疗前均有改善(P0.05),对照组仅在改善血尿、咽喉红肿疼痛、腰痛、肢体麻木方面有较好疗效(P0.05),并且疗效不及治疗组(P0.05)。两组均可以显著地改善中医症候(P0.01),治疗组在改善中医症候方面优于对照组(P0.01)。在24h尿蛋白定量及尿红细胞方面,两组治疗后均较治疗前有明显改善(P0.01),治疗组优于对照组(P0.05)。治疗组的临床疗效优于对照组(P0.01)。两组治疗对肾功能无明显影响。结论:解毒活血方治疗瘀毒互结型IgA肾病疗效明显,在改善症状,减少蛋白尿、血尿方面优于对照组,显示出解毒活血方的优势。
[Abstract]:Objective: to observe the clinical curative effect of jiedu Huoxue prescription in treating IgA nephropathy with blood stasis and toxin, so as to give full play to the advantages of traditional Chinese medicine, improve the treatment level and improve the quality of life of patients. Methods: 60 patients with IgA nephropathy were randomly divided into treatment group (n = 30) and control group (n = 30). The control group was treated with anti-infection, anticoagulant, hypotensive, lipid-regulating and other western medicine treatments. The treatment group was treated with jiedu Huoxue recipe for 4 weeks on the basis of western medicine treatment. After 2 courses of treatment, the urine red blood cell count was observed and 24 hours urine protein was measured. The changes of serum creatinine and urea nitrogen were evaluated by quantification of symptoms and signs. Results: the total effective rate was 83.3 in the treatment group and 60.0 in the control group. The total effective rate in the treatment group was higher than that in the control group (P 0.01). The symptoms in the treatment group were improved before treatment (P 0.05), while in the control group there was a better effect in improving hematuria, sore throat, low back pain and limb numbness, and the curative effect was not as good as that in the treatment group. Both groups could significantly improve the symptoms of traditional Chinese medicine (P0.01A), and the treatment group was better than the control group in improving the symptoms of TCM. In 24 hours urine protein quantity and urine red blood cell, the two groups had obvious improvement compared with before treatment, the treatment group was superior to the control group (P 0.05). The clinical effect of the treatment group was better than that of the control group (P 0.01). There was no significant effect on renal function in both groups. Conclusion: jiedu Huoxue prescription has obvious effect on treating IgA nephropathy with blood stasis and toxin, which is superior to the control group in improving symptoms, reducing proteinuria and hematuria, showing the advantage of jiedu Huoxue prescription.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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