明曲降脂茶治疗痰湿型非酒精性脂肪肝的临床观察

发布时间：2018-06-21 06:18

本文选题：明曲降脂茶 + 痰湿型　；参考：《辽宁中医药大学》2016年硕士论文

【摘要】：目的:观察明曲降脂茶治疗痰湿型非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)的临床疗效和安全性,并探讨其作用机制。材料与方法:按纳入标准将159例痰湿型NAFLD患者根据随机数字表法分为茶饮组79例和对照组80例。两组分别给予明曲降脂茶和强肝胶囊口服治疗。密切监测患者各安全性观察指标。对两组患者在中医证候,BMI及WC,血清生化指标:(1)血脂:TC、TG、HDL-C、LDL-C;(2)肝功能:ALT、AST、GGT,肝脏超声分度的改善情况应用SPSS22.0统计分析软件进行判定。并嘱两组患者在12周的治疗期间注意调整饮食结构,减少碳水化合物的摄入,尤其是含有高糖的软饮料。多食蔬菜水果并禁酒;控制体重同时加强有氧运动锻炼。结果:1.茶饮组和对照组患者治疗前在性别、年龄、病程方面比较,差异无统计学意义(P0.05),具有可比性。2.治疗后总有效率茶饮组为87.2%,对照组为86.1%,经分析,差异无统计学意义(P0.05)。表明两组药物治疗痰湿型NAFLD疗效相当。3.两组药物在改善患者的中医证候和肝脏影像学方面差异无统计学意义(P0.05)。4.治疗后茶饮组和对照组患者的各观察指标与治疗前比较均明显改善(P0.01)。5.茶饮组在改善患者血脂、BMI及WC方面均优于对照组(P0.01,P0.05)。6.对照组在降低患者ALT方面优于茶饮组(P0.01)。结论:1.明曲降脂茶在改善痰湿型NAFLD患者的中医证候、肝功能及肝脏超声分度方面与强肝胶囊疗效相当。2.明曲降脂茶可有效改善痰湿型NAFLD患者BMI及WC水平。3.明曲降脂茶可有效改善痰湿型NAFLD患者血脂各观察指标。
[Abstract]:Objective: to observe the clinical efficacy and safety of Mingqu Jiangzhi tea in the treatment of non-alcoholic fatty liver disease of phlegm-dampness type non-alcoholic fatty liver disease (NAF LDD), and to explore its mechanism. Materials and methods: 159 NAFLD patients with phlegm dampness type were randomly divided into tea drinking group (79 cases) and control group (80 cases). The two groups were treated orally with Mingqu Jiangzhi tea and Qianggan capsule respectively. The safety indexes of patients were closely monitored. The improvement of liver function was determined by SPSS 22.0 statistical analysis software in the two groups in TCM syndromes, BMI and WC, serum biochemical index: 1) blood lipid: TCG, HDL-CU LDL-CU 2) liver function: ALT ASTT GGT.The improvement of liver ultrasonic grading was determined by SPSS 22.0 statistical analysis software. Patients in both groups were advised to adjust their diet and reduce carbohydrate intake, especially high-sugar soft drinks, during 12 weeks of treatment. Eat more vegetables and fruits and ban alcohol; control weight and strengthen aerobic exercise. The result is 1: 1. There was no significant difference in sex, age and course of disease between the tea drinking group and the control group before treatment (P 0.05). The total effective rate after treatment was 87.2 in the tea drinking group and 86.1 in the control group. The difference was not statistically significant (P 0.05). The results showed that the therapeutic effect of two drugs on phlegm dampness type NAFLD was equivalent to 3. 3. There was no significant difference between the two groups in improving TCM syndromes and liver imaging. After treatment, the observation indexes of tea drinking group and control group were significantly improved compared with those before treatment. The tea drinking group was superior to the control group in improving blood lipid BMI and WC. The control group was superior to the tea drink group in reducing the alt of the patients (P 0.01). Conclusion 1. The curative effect of Mingqu Jiangzhi tea on improving TCM syndromes, liver function and liver ultrasonic grading of NAFLD patients with phlegm dampness was equivalent to that of Qianggan capsule. Mingqu Jiangzhi tea can effectively improve BMI and WC level of NAFLD patients with phlegm dampness type. Mingqu Jiangzhi tea can effectively improve the observation indexes of blood lipid in patients with phlegm dampness type NAFLD.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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