安神汤治疗心肾不交型失眠症的临床研究

发布时间：2018-06-21 06:19

本文选题：安神汤 + 心肾不交型　；参考：《长春中医药大学》2016年硕士论文

【摘要】：目的:本研究采用随机对照方法,以心肾不交型失眠症患者中医证候评分、匹兹堡睡眠质量指数及多导睡眠图监测数据为观察指标来评价安神汤治疗心肾不交型失眠症的临床疗效及安全性,为治疗心肾不交型失眠症提供新思路,指导临床实践。方法:应用随机数字表法将符合纳入标准的72例心肾不交型失眠症患者随机分为治疗组与对照组,各36例,治疗组口服安神汤,对照组口服右佐匹克隆片,治疗4周,结束后观察治疗前后中医证候评分、匹兹堡睡眠质量指数评分,多导睡眠图监测各指标的变化来评定其疗效及安全性,停药1周后对两组患者进行随访,观察两组失眠复发情况。结果:临床共入组患者72例(治疗组36例,脱落1例;对照组36例,脱落1例),治疗前对基线资料中年龄、性别等进行比较,两组具有可比性(P0.05)。1.治疗组总有效率为85.87%,对照组总有效率88.57%,两组间总有效率比较,差异无统计学意义(P0.05)。2.两组患者中医证候评分较治疗前均改善(P0.05),治疗组优于对照组(P0.05)。3.两组患者PSQI评分较治疗前均降低(P0.05),两组间PSQI评分比较,差异无统计学意义(P0.05)。4.两组患者多导睡眠仪监测指标(总睡眠时间、睡眠潜伏期时间、觉醒次数和非快速眼动睡眠时间)较治疗前均改善(P0.05),两组间各指标比较,差异无统计学意义(P0.05)。5.停药1周后随访,治疗组患者PSQI评分与治疗后比较,差异无统计学意义(P0.05),但对照组患者PSQI评分较治疗后增高(P0.05),停药1周后两组PSQI评分比较,治疗组优于对照组(P0.05)。结论:安神汤治疗心肾不交型失眠与右佐匹克隆的总疗效相似,但在改善中医证候方面优于右佐匹克隆,且无依赖性及明显副作用,安全有效。
[Abstract]:Objective: the purpose of this study was to evaluate the TCM syndromes of patients with heart-kidney disjoint insomnia by using a randomized controlled method. Pittsburgh sleep quality index and polysomnography monitoring data were used to evaluate the clinical efficacy and safety of Anshen decoction in the treatment of heart and kidney disjoint insomnia, to provide a new idea for the treatment of heart and kidney disjoint insomnia, and to guide clinical practice. Methods: Seventy-two patients with insomnia of heart and kidney disjoint type were randomly divided into treatment group (n = 36) and control group (n = 36). The treatment group was treated with Anshen decoction and the control group was treated with right zopicone tablet for 4 weeks. After the treatment, the TCM syndrome score, Pittsburgh Sleep quality Index score and polysomnography were observed before and after treatment to assess the efficacy and safety of the two groups. The recurrence of insomnia was observed in both groups. Results: there were 72 patients (36 cases in the treatment group, 1 case in the control group). Before the treatment, the age and sex of the baseline data were compared, and the two groups were comparable. The total effective rate was 85.87 in the treatment group and 88.57 in the control group. There was no significant difference in the total effective rate between the two groups. The TCM syndrome score of the two groups was improved compared with that before treatment, and that of the treatment group was better than that of the control group. The PSQI scores of the two groups were significantly lower than those of before treatment. There was no significant difference in PSQI scores between the two groups. The monitoring indexes of polysomnography (total sleep time, sleep latency time, arousal time and non-rapid eye movement sleep time) in the two groups were improved compared with those before treatment (P 0.05). There was no significant difference between the two groups (P 0.05). There was no significant difference in PSQI score between the treatment group and the control group, but the PSQI score in the control group was higher than that in the control group. The PSQI score in the treatment group was higher than that in the control group after one week. The PSQI score in the treatment group was better than that in the control group (P 0.05). Conclusion: the total curative effect of Anshen decoction in treating insomnia of heart and kidney disjoint type is similar to that of right zopicron, but it is superior to right zopicron in improving TCM syndromes, and it has no dependence and obvious side effects, so it is safe and effective.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.23

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