固本润肠膏对脾肾阳虚型便秘患者血管活性肠肽、P物质影响的临床研究

发布时间：2018-06-22 14:02

  本文选题：固本润肠膏 + 脾肾阳虚　； 参考：《安徽中医药大学》2016年硕士论文

【摘要】：目的通过观察固本润肠膏对脾肾阳虚型便秘患者血管活性肠肽、P物质的影响,将其观察指标、副作用及不良反应等方面与服用琥珀酸普鲁卡必利的患者进行比较,了解其在以上各方面优于后者之处,为固本润肠膏在临床广泛应用中提供数字化的客观的科学的支撑,以提高该病患者的治疗效果。方法用软件制作随机码将100例符合条件并且已纳入临床实验研究的患者随机的分为治疗组(口服固本润肠膏,温服,早中晚各20毫升)和对照组(口服琥珀酸普鲁卡必利,1毫克每晚)各50例。比较两组患者在年龄大小、病程长短、性别比例、病情轻重程度等方面的差异,得出P值均大于0.05,说明两组患者在以上各方面的差异均没有明显的统计学意义。共设3个治疗阶段,每一治疗阶段均设为28天。了解并记录标本病例各个观察指标,并在三个阶段结束后28天观察患者是否出现病情复发的情况。临床指标:记录所有标本病例服药前一周及每一疗程最后一周的排便次数以及单次排便的时间;记录患者开始服药前一天及疗程结束后一天的中医证候积分。实验室指标:全部受检者自开始服药前1日及每一疗程结束后1日晨空腹抽取肘静脉血6ml(用肝素钠抗凝),用干净试管收集血液,所有血标本以3000r/min离心15分钟,吸取血清放置于-80℃冰箱内保存,待治疗结束并收集齐所有血清标本,再统一检测并记录实验得出VIP值、SP值。影像学指标:结肠传输实验:服药前检查结肠传输实验,停药后3天复查,观察治疗后结肠传输改善率。标本病例各个观察指标的结果均采用两独立样本的t检验进行比较,P值小于0.05说明指标间的差异具有统计学意义。标本病例各项观察指标及基本信息的记录与比较,均采用SPASS17.0统计软件包。结果比较治疗组和对照组标本病例的各项观察指标,VIP、SP、单周排便次数、单次排便时间、结肠传输实验、中医证候积分、及复发率方面,P值均小于0.05或0.01,且在治疗过程中,标本病例均未出现药物不良反应。结论固本润肠膏在治疗脾肾阳虚型便秘方面较琥珀酸普芦卡必利有着明显的优势,对脾肾阳虚型便秘患者的各项观察指标均有着明显的改善。实验结果显示,固本润肠膏治疗脾肾阳虚型便秘不仅疗效好,且副作用及复发率低,适合在临床上广泛应用于该类型便秘患者。
[Abstract]:Objective to observe the effect of Guben Runchang ointment on vasoactive intestinal peptide substance P in patients with constipation with deficiency of spleen and kidney yang, and compare its observation index, side effects and adverse reactions with those of patients taking prucapride succinate. To understand the advantages of Guben Runchang ointment in all aspects above, to provide digital and objective scientific support for the wide application of Guben Runchang ointment in clinic, so as to improve the therapeutic effect of Guben Runchang ointment. Methods 100 patients who met the criteria and were included in the clinical trial were randomly divided into treatment group (oral Guben Runchang ointment, warm suit). Early, mid-evening, 20 ml) and control group (oral 1 mg of prapiride succinate, 50 cases per night). The difference of age, duration of disease, sex ratio, severity of disease and so on were compared between the two groups. The P value was more than 0.05, which indicated that there was no significant difference between the two groups in the above aspects. There were 3 treatment stages, each of which was set up for 28 days. To understand and record the observed indexes of the specimen and observe whether the patient has relapse 28 days after the end of the three stages. Clinical indicators: the number of defecation and the time of single defecation were recorded one week before taking the medicine and the last week of each course of treatment, and the TCM syndromes scores of the patients before and after the course of treatment were recorded. Laboratory indicators: all the subjects collected 6ml (anticoagulant with heparin sodium) from the elbow vein on an empty stomach 1 day before and after each course of treatment, and collected the blood with a clean tube. All blood samples were centrifuged with 3000r/min for 15 minutes. The collected serum was stored in the refrigerator at -80 鈩，

本文编号：2053060