醒脾养肝汤治疗酒精性肝病对肝功能、肝纤维化相关指标的影响

发布时间：2018-06-23 09:55

本文选题：酒精性 + 肝疾病　；参考：《中华中医药学刊》2017年03期

【摘要】：目的:探讨自拟醒脾养肝汤治疗酒精性肝病的临床疗效,并分析对肝功能、肝纤维化相关指标的影响。方法:选取酒精性肝病患者82例,根据治疗方法不同将其分为观察组(42例)与对照组(40例)。对照组给常规综合治疗,观察组在给予常规综合治疗的基础上外加给予自拟醒脾养肝汤治疗。治疗后对两组临床疗效进行比较,并对两组患者治疗前后肝功能、肝纤维化相关指标的变化情况进行观察。结果:在临床疗效方面,观察组治疗总有效率85.7%与对照组治疗总有效率67.5%相比显著提高,差异有统计学意义(P0.05)。与治疗前比较,两组治疗后期肝功能、肝纤维化指标均明显改善,差异具有统计学意义(P0.05),且观察组改善情况显著优于对照组(P0.05);经彩色多普勒超声检查显示,与治疗前相比,两组治疗后其静脉内径、脾静脉内径及脾肿大程度均明显减小,差异具有统计学意义(P0.05),且观察组改善程度显著优于对照组(P0.05)。结论:自拟醒脾养肝汤治疗酒精性肝病具有显著的临床疗效,同时能够有效改善肝功能及肝纤维化水平,值得临床进一步推广与应用。
[Abstract]:Objective: to investigate the clinical effect of Xingpi Yanggan decoction on alcoholic liver disease, and to analyze the effect on liver function and liver fibrosis. Methods: 82 patients with alcoholic liver disease were divided into observation group (42 cases) and control group (40 cases) according to different treatment methods. The control group was treated with routine comprehensive therapy, the observation group was treated with self-made decoction of Xingpi Yanggan on the basis of routine comprehensive treatment. The changes of liver function and hepatic fibrosis were observed before and after treatment. Results: the total effective rate of the observation group was 85.7% and that of the control group was 67.5%. The difference was statistically significant (P0.05). Compared with before treatment, the liver function and hepatic fibrosis index of the two groups were improved significantly (P0.05), and the improvement of the observation group was significantly better than that of the control group (P0.05). After treatment, the diameter of the vein, the diameter of the splenic vein and the degree of splenomegaly decreased significantly in the two groups, the difference was statistically significant (P0.05), and the improvement of the observation group was significantly better than that of the control group (P0.05). Conclusion: the self-made decoction of tonifying spleen and nourishing liver has a remarkable clinical effect on alcoholic liver disease, and can effectively improve liver function and liver fibrosis level, which is worthy of further clinical promotion and application.
【作者单位】：宁波市第一医院中医科;
【分类号】：R259

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