杏灵分散片对脑梗死患者颈动脉粥样硬化程度和血清炎症因子的影响

发布时间：2018-06-30 09:25

本文选题：杏灵分散片 + 脑梗死　；参考：《中国动脉硬化杂志》2017年07期

【摘要】：目的观察杏灵分散片对脑梗死患者颈动脉粥样硬化程度和血清炎症因子水平的影响,及美国国立卫生研究院卒中量表评分(NIHSS)改善情况,以探讨杏灵分散片治疗价值。方法选择98例伴有颈动脉粥样硬化斑块的脑梗死患者,随机分为常规治疗组和杏灵分散片组,杏灵分散片组在常规治疗的基础上加服杏灵分散片,疗程3个月,观察两组治疗前后NIHSS评分、颈总动脉粥样硬化斑块面积和颈动脉内膜中膜厚度(IMT)的变化,同时观察血清C反应蛋白(CRP)、同型半胱氨酸(Hcy)和白细胞介素1β(IL-1β)的变化。结果治疗前杏灵分散片组及常规治疗组NIHSS评分、斑块面积和IMT比较无明显差异(P0.05),治疗后均明显降低(P0.001);杏灵分散片组治疗后NIHSS评分、斑块面积和IMT小于常规治疗组治疗后(P0.001)。两组CRP、Hcy和IL-1β治疗前无明显差异(P0.05),治疗后均较治疗前下降(P0.001);杏灵分散片组治疗后CRP、Hcy和IL-1β均低于常规治疗组治疗后(P0.001)。结论杏灵分散片可能通过抑制炎症作用,延缓颈动脉粥样硬化的进展,达到改善神经功能缺损的作用。
[Abstract]:Objective to observe the effect of Xingling dispersible tablets on the degree of carotid atherosclerosis and the level of serum inflammatory factors in patients with cerebral infarction, and to explore the therapeutic value of Xingling dispersible tablets in the treatment of stroke scale score (NIHSS) of the National Institutes of Health (NIH). Methods 98 patients with cerebral infarction with carotid atherosclerotic plaque were randomly divided into routine treatment group and Xingling dispersible tablet group. Xingling dispersible tablet group was treated with Xingling dispersible tablet on the basis of routine treatment for 3 months. NIHSS score, carotid atherosclerotic plaque area, carotid intima media thickness (IMT), serum C-reactive protein (CRP), homocysteine (Hcy) and interleukin-1 尾 (IL-1 尾) were observed before and after treatment. Results there was no significant difference in NIHSS score, plaque area and IMT between Xingling dispersible tablet group and routine treatment group (P0.05), and the NIHSS score, plaque area and IMT in Xingling dispersible tablet group after treatment were significantly lower than those in routine treatment group (P0.001). There was no significant difference between the two groups before and after treatment (P0.05), both decreased after treatment (P0.001), and the levels of Hcy and IL-1 尾 in Xingling dispersible tablets group were lower than those in the routine treatment group (P0.001). Conclusion Xingling dispersible tablets may delay the progression of carotid atherosclerosis by inhibiting inflammation and improve the neurological function.
【作者单位】：南华大学附属南华医院神经内科;
【分类号】：R277.7

【参考文献】