菊翘解毒中药面膜治疗中度寻常痤疮的临床疗效和安全性观察

发布时间：2018-07-01 21:52

本文选题：寻常痤疮 + 随机对照　；参考：《北京中医药大学》2017年硕士论文

【摘要】：研究背景寻常痤疮(Acne Vulgaris)是一种皮肤科常见的毛囊皮脂腺的慢性炎症性疾病。大多数青少年患过痤疮,个别患者可以迁延至成年以后。现代医学认为,遗传倾向和性激素水平可能在寻常痤疮患者中发挥作用。其发病机理主要有四个要素:皮脂分泌的增加,毛囊皮脂腺导管的角化异常,毛囊部细菌的定殖和炎症反应。由于其皮疹主要在发生在颜面,炎症消退后留有色素沉着,并且可能导致长期持续的疤痕,对患者的身心健康皆造成不可忽视的影响。西药的各种不良反应使其在痤疮治疗中的应用受到一定限制。中医药治疗痤疮一直是医生们的研究热点,其中特色的外治疗法,在痤疮治疗中具有重要作用。中药外治痤疮历史悠久,现代文献研究表明许多中药面膜治疗寻常痤疮取得了一定疗效,且很少出现不良反应。研究目的探索北京中医医院菊翘解毒中药面膜单独外用治疗中度寻常痤疮的临床疗效和安全性。研究方法本试验采用前瞻性的研究方法,随机、患者单盲、安慰剂对照的研究设计,将55位中度(国际改良痤疮分级法)痤疮患者随机分为两组,即试验组(36人)和安慰剂组(19人),分别用北京中医医院菊翘解毒中药面膜和安慰剂面膜单独外用治疗1月。研究结果北京中医医院菊翘解毒中药面膜单独外用治疗青春期后中度寻常痤疮患者有效率显著高于安慰剂组,其中3例患者出现面部黄色色染,1例用面膜后出现轻度面部痒感,均无需处理可自行缓解。结论北京中医医院菊翘解毒中药面膜单独外用治疗中度寻常痤疮患者有一定的疗效且安全。
[Abstract]:Background Acne vulgaris (Acne Vulgaris) is a common chronic inflammatory disease of hair follicle sebaceous gland in dermatology. Most adolescents have acne, and individual patients can be extended into adulthood. Modern medicine suggests that genetic predisposition and sex hormone levels may play a role in acne vulgaris. There are four main factors in the pathogenesis: the increase of sebum secretion, the abnormal keratosis of hair follicle sebaceous gland catheter, the colonization and inflammatory reaction of hair follicle bacteria. As the rash mainly occurs in the face, the inflammation subsided with pigmentation, and may lead to long-term scars, which can not be ignored on the physical and mental health of patients. The adverse effects of western medicine restrict its application in acne treatment. Traditional Chinese medicine (TCM) treatment of acne has always been a hot topic for doctors, among which the characteristic external therapy plays an important role in the treatment of acne. There is a long history of external treatment of acne with traditional Chinese medicine. Modern literature studies show that many traditional Chinese medicine masks have achieved a certain curative effect on acne vulgaris, and there are few adverse reactions. Objective to explore the clinical efficacy and safety of Ju Qiao detoxification traditional Chinese medicine mask in the treatment of moderate acne vulgaris. Methods the study was conducted in a prospective, randomized, single-blind, placebo-controlled study in which 55 moderate acne patients were randomly divided into two groups. The trial group (36 cases) and the placebo group (19 cases) were treated with Chinese medicine mask and placebo mask for 1 month respectively. Results the effective rate of treating moderate acne vulgaris after puberty was significantly higher than that in the placebo group. Can be relieved by itself without any treatment. Conclusion it is safe and effective to treat moderate acne vulgaris with traditional Chinese medicine mask for detoxification of chrysanthemum in Beijing traditional Chinese Medicine Hospital.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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