氨甲苯酸创腔局部用药对全髋置换术后出血的影响

发布时间：2018-07-03 10:57

本文选题：氨甲苯酸 + 局部用药　；参考：《广西中医药大学》2016年硕士论文

【摘要】：目的:观察氨甲苯酸创腔局部用药对全髋关节置换术后出血的影响,评价氨甲苯酸的止血的有效性及安全性。方法:本研究采取前瞻性随机对照研究,选取2014.1~2016.1符合入选要求的90例行单侧初次全髋关节置换术的患者,其中男55例,女35例,根据术后创腔不同用药随机分为三组:A组30例,将氨甲苯酸注射液(10ml:0.1g),3支溶于20ml生理盐水中,在关闭切口后经引流管逆行推注入关节腔,B组30例,将氨甲环酸粉针(0.5g)2支溶于50ml生理盐水中,在关闭切口后经引流管逆行推注入关节腔,C组30例将50ml生理盐水,在关闭切口后经引流管逆行推注入关节腔。三组术后均夹闭引流管4小时。统计各组患者的术后48小时引流量、输血人数、术后第一天和第三天血红蛋白及红细胞压积值等评价指标,以观察氨甲苯酸注射液止血效果。结果:入选90例患者均完成了整个治疗过程,无一例脱落。术前三组患者在性别、年龄、身高、体重、体重指数、病种、术前血红蛋白及红细胞压积指标比较差异无统计学意义(P0.05),具有可比性;术后引流量、输血人数A组和B组都小于C组(P0.05),A组和B组在输血人数、术后血红蛋白及红细胞压积方面无明显差异(P0.05)。三组患者均未出现双下肢深静脉血栓及肺栓塞。结论:氨甲苯酸创腔局部用药能明显降低全髋关节置换术后引流量及输血人数,氨甲苯酸和氨甲环酸二者在减少全髋关节置换术后引流量及输血人数上影响水平相当,而且并未增加下肢深静脉血栓和肺栓塞形成的风险。氨甲苯酸价格低廉、创腔局部用药安全性高,是值得推广的一种止血方式。
[Abstract]:Objective: to observe the effect of local administration of aminomethylbenzoic acid on bleeding after total hip arthroplasty and to evaluate the efficacy and safety of aminobenzoic acid in hemostasis. Methods: a prospective randomized controlled study was conducted in which 90 patients (55 males and 35 females) with unilateral primary total hip arthroplasty were randomly divided into three groups according to the different drugs used in the invasive cavity: group A (30 cases), and group A (30 cases). Three branches of aminomethylbenzoic acid injection (10ml:0.1g) were dissolved in 20ml saline. After closing the incision, 30 cases of group B were retrogradely injected with drainage tube after closure of the incision. Two of them (0.5 g) were dissolved in normal saline of 50ml. After closing the incision, 30 patients in group C were injected with 50ml normal saline retrograde through drainage tube, and then retrograde pushed into the joint cavity by drainage tube after closure of incision. The drainage tubes were clamped for 4 hours after operation in all three groups. In order to observe the hemostatic effect of aminobenzoic acid injection, the drainage flow, the number of blood transfusion, hemoglobin and hematocrit on the first day and the third day after operation were calculated and analyzed in order to observe the hemostatic effect of aminobenzoic acid injection. Results: 90 patients completed the whole course of treatment, none of them dropped off. There was no significant difference in sex, age, height, body mass index, disease, hemoglobin and hematocrit between the three groups before operation (P0.05). The number of blood transfusion in group A and group B was lower than that in group C (P0.05). There was no significant difference in the number of blood transfusion, hemoglobin and hematocrit after operation (P0.05). No deep venous thrombosis and pulmonary embolism were found in the three groups. Conclusion: local administration of aminomethylbenzoic acid can significantly reduce the drainage volume and the number of blood transfusions after total hip arthroplasty. The effect of aminomethylbenzoic acid and aminomethacin on the volume of drainage and the number of blood transfusions after total hip replacement is the same. There was no increased risk of deep venous thrombosis and pulmonary embolism in the lower extremities. Aminobenzoic acid is a kind of hemostatic method worth popularizing because of its low price and high safety.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9

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