加味升阳益胃汤治疗溃疡性结肠炎缓解期脾肾阳虚证的临床观察

发布时间：2018-07-04 08:36

本文选题：溃疡性结肠炎缓解期 + 升阳益胃汤　；参考：《山西省中医药研究院》2016年硕士论文

【摘要】：目的:观察加味升阳益胃汤对溃疡性结肠炎缓解期脾肾阳虚证的临床疗效和安全性观察。方法:选择符合纳入标准的溃疡性结肠炎缓解期病例60例,随机分为治疗组和对照组各30例,治疗组口服中药汤剂联合美沙拉嗪肠溶片,对照组口服美沙拉嗪肠溶片,治疗2个月后,观察两组临床疗效的差异,6个月后观察两组的复发率。结果:治疗组与对照组两组间综合疗效经统计学分析P0.05,差异有统计学意义;两组在控制中医症状方面,治疗组的有效率为76.7%,对照组的有效率为70%,经统计学分析结果为P0.05,差别有统计学意义,说明治疗组在控制中医证候方面有优势。治疗前后结肠镜情况的比较,治疗组的有效率为73.3%,对照组的有效率为70%,经统计学分析结果为P0.05,差别有统计学意义,说明治疗组在改善结肠镜情况方面有优势。治疗后,两组T细胞亚群中CD3、CD4、CD8的值的改变经统计分析结果为P0.05,差别有统计学意义,CD4/CD8的统计分析结果为P0.05,差异无统计学意义。治疗后两组的复发率,对照组的复发率为16.7%,治疗组的复发率为10%,经统计学分析结果为P0.05,差别有统计学意义。结论:加味升阳益胃汤治疗溃疡性结肠炎缓解期,能有效的改善症状,有效的维持缓解防止复发;同时能改善机体免疫力。
[Abstract]:Objective: to observe the clinical effect and safety of Jiawei Shengyang Yiwei decoction on spleen and kidney yang deficiency syndrome in remission of ulcerative colitis. Methods: sixty patients with ulcerative colitis in remission period were randomly divided into two groups: the treatment group (n = 30) and the control group (n = 30). After 2 months of treatment, the difference of clinical efficacy between the two groups was observed, and the recurrence rate of the two groups was observed after 6 months. Results: the comprehensive curative effect of the treatment group and the control group was statistically analyzed by statistical analysis (P0.05), the difference was statistically significant, the two groups in the control of TCM symptoms, The effective rate of the treatment group was 76.7g and that of the control group was 70.The result of statistical analysis was P0.05. the difference was statistically significant, which indicated that the treatment group had advantages in controlling TCM syndromes. The comparison of colonoscopy before and after treatment showed that the effective rate was 73.3 in the treatment group and 70 in the control group. The difference was statistically significant, which indicated that the treatment group had advantages in improving the colonoscopy. After treatment, the changes of CD3, CD4 and CD8 in T cell subsets of the two groups were P0.05 and P0.05, respectively. The difference of CD4 / CD8 was P0.05. there was no significant difference between the two groups. After treatment, the recurrence rate of the two groups, the control group is 16.7, the treatment group of the recurrence rate is 10, the result of statistical analysis is P0.05, the difference is statistically significant. Conclusion: Jiawei Shengyang Yiwei decoction can effectively improve symptoms, maintain remission and prevent recurrence, as well as improve body immunity in the treatment of ulcerative colitis in remission period.
【学位授予单位】：山西省中医药研究院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】