疏风清肺止咳方治疗感染后咳嗽风热郁肺证的临床研究

发布时间：2018-07-04 18:13

本文选题：感染后咳嗽 + 风热郁肺证　；参考：《湖南中医药大学》2016年硕士论文

【摘要】：目的:观察疏风清肺止咳方治疗感染后咳嗽风热郁肺证的临床疗效,并对其安全性及有效性进行评估。方法:将符合纳入标准的60例感染后咳嗽患者随机分为治疗组(30例)和对照组(30例),治疗组给予疏风清肺止咳方汤剂治疗,对照组给予复方甲氧那明胶囊联合维生素C片口服治疗,观察疗程均为7天。通过观察治疗前后两组视觉模拟评分(VAS),中医证候分级量化评分,咳嗽起效时间,疾病总疗程等指标以评估临床疗效。结果:(1)两组总体疗效比较,治疗组总有效率93.33%与对照组(70%)比较,差异有统计学意义(P0.05),说明治疗组总有效率高于对照组。(2)两组视觉模拟评分比较,治疗后治疗组视觉模拟评分2.57?1.89,对照组3.76?2.07,差异有统计学意义(P0.05),说明治疗组在缓解咳嗽症状方面优于对照组。(3)两组主症积分比较,治疗后治疗组主症积分为3.20?2.07,对照组为5.91?3.18,差异具有统计学意义(P0.05),说明在改善主症上,治疗组较对照组优。(4)两组次症积分比较,两组疗后咽干,便干症状积分比较,治疗组优于对照组(P0.05),说明治疗组在缓解咽干、便干症状方面效果更佳;两组疗后在咳痰、口干症状积分方面比较,两组差异均无统计学意义(P0.05),说明两组在缓解咳痰、口干症状效果相当;(5)两组中医证候总积分比较,疗后治疗组中医证候总积分为3.77?1.76,与对照组为7.09?1.92比较,差异有统计学意义(P0.05),说明治疗组在缓解感染后咳嗽中医症状方面优于对照组。(6)两组咳嗽起效时间比较,治疗组咳嗽平均起效时间为30.40?9.20h,对照组为32.80?10.42h,差异无统计学意义(P0.05),说明两组咳嗽起效时间相当。(7)两组疾病疗程比较,治疗组疾病平均疗程为4.95?0.92天,对照组为5.57?1.05天,差异有统计学意义(P0.05),说明在疾病疗程上,治疗组短于对照组。结论:疏风清热止咳方在治疗感染后咳嗽风热郁肺证具有良好临床疗效,且可缩短疾病疗程,未见明显不良反应。
[Abstract]:Objective: to observe the clinical effect of Shufeng Qingfei Zhike recipe in treating cough wind heat depression lung syndrome after infection, and to evaluate its safety and effectiveness. Methods: sixty patients with post-infection cough were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Shufeng Qingfei Zhike decoction. The control group was treated with compound methoxylamine capsule combined with vitamin C tablet orally for 7 days. The clinical efficacy was evaluated by observing the visual analogue score (VAS), the quantitative score of TCM syndromes, the onset time of cough and the total course of treatment before and after treatment. Results: (1) the total effective rate of the treatment group was 93.33% compared with the control group (70%), the difference was statistically significant (P0.05), which indicated that the total effective rate of the treatment group was higher than that of the control group. (2) the visual analogue score of the two groups was higher than that of the control group. After treatment, the visual analogue score of the treatment group was 2.57 ~ 1.89, while that of the control group was 3.76 ~ 2.07, the difference was statistically significant (P0.05), which indicated that the treatment group was superior to the control group in relieving cough symptoms. (3) the main symptom scores of the two groups were compared. After treatment, the score of main symptom in the treatment group was 3.20 卤2.07, and that in the control group was 5.91 卤3.18, the difference was statistically significant (P0.05), which indicated that the treatment group was superior to the control group in improving the main symptom. (4) the score of the two groups was higher than that of the control group. The treatment group was superior to the control group (P0.05), indicating that the treatment group was more effective in relieving the symptoms of dry pharynx and dry stool; after treatment, there was no significant difference between the two groups in the score of expectoration and dry oral symptoms (P0.05), which indicated that the two groups had no significant difference in relieving expectoration. (5) the total score of TCM syndromes in the treatment group was 3.77 ~ 1.76, and that in the control group was 7.09 ~ 1.92, compared with that in the control group, (5) the total score of TCM syndromes in the treatment group was 3.77 ~ 1.76 and 7.09 ~ 1.92 respectively. The difference was statistically significant (P0.05), indicating that the treatment group was superior to the control group in relieving the symptoms of cough after infection. (6) the time of onset of cough in the two groups was higher than that in the control group. The average onset time of cough in the treatment group was 30.40 卤9.20 h, and that in the control group was 32.80 卤10.42 h. The difference was not statistically significant (P0.05), which indicated that the onset time of cough was the same between the two groups. (7) the average course of treatment was 4.95 卤0.92 days in the treatment group and 5.57 卤1.05 days in the control group. The difference was statistically significant (P0.05), indicating that the treatment group was shorter than the control group in the course of treatment. Conclusion: Shufeng Qingre Zhike prescription has good clinical effect in treating cough with wind-heat depression and lung syndrome after infection and can shorten the course of disease without obvious adverse reactions.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.11

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