中医药治疗抗精神药物引起多汗症的研究进展

发布时间：2018-07-05 15:11

本文选题：抗精神药物 + 多汗症　；参考：《世界中医药》2017年01期

【摘要】：多汗症是精神药物的常见不良反应,其发生机制目前尚不明确。文章从精神药物引起多汗症的机制,以及中医药治疗此类多汗症的作用机理的进展作一综述。应用计算机检索PUBMED 1993年至2016年期间与抗精神病药物、多汗症、中医、中药、针灸等相关的文献,关键词"Psychotropic Drugs and Hyperhidrosis",同时计算机检索相关杂志1986年1月至2016年3月期间与精神药物、多汗症、中医、中药、针灸相关的文献,限定语种为"中文"和"英文",关键词"精神药物、多汗症、中医药"。选择资料:纳入标准为临床研究、实验研究类文献及临床案例报导类文献。检索发现:精神药物引起多汗症是临床很常见的症状,其发病机制与精神药物的多靶点作用有关,尤其是抗抑郁药,发生出汗的不良反应比例较高,可能与选择性的5-羟色胺再摄取抑制机制相关。治疗方面,西医直接阻断出汗通路或者外用药物止汗,不良发应较大;中医认为自汗、盗汗的基本病机是阴阳失调,腠理不固而致汗液外泄失常。中医通过服用单味药、复方及针刺疗法,取得较好疗效。在今后研究中需着重探讨其发病机制,收集更多临床案例进行观察,并实施规范化治疗。
[Abstract]:Hyperhidrosis is a common adverse reaction of psychotropic drugs, and its mechanism is unclear. This article reviews the mechanism of hyperhidrosis induced by psychoactive drugs and the progress in the treatment of hyperhidrosis by traditional Chinese medicine. To search the literature related to antipsychotics, hyperhidrosis, traditional Chinese medicine, Chinese medicine, acupuncture and moxibustion between 1993 and 2016, the key word "Psychotropic Drugs and Hyperhidrosis" was searched by computer, and the related journals were searched for the period from January 1986 to March 2016. Hyperhidrosis, Chinese medicine, Chinese medicine, acupuncture and moxibustion related literature, limited language for "Chinese" and "English", the keyword "psychotropic drugs, hyperhidrosis, Chinese medicine." Selected data: inclusion criteria for clinical studies, experimental studies and clinical case reports. It was found that hyperhidrosis caused by psychotropic drugs is a common clinical symptom. The pathogenesis of hyperhidrosis is related to the multi-target effect of psychoactive drugs, especially antidepressants, with a high incidence of adverse reactions to sweating. It may be related to selective 5-hydroxytryptamine reuptake inhibition mechanism. For treatment, Western medicine directly block the sweating pathway or external use drugs to stop sweating, bad hair should be larger; Chinese medicine think that the basic pathogenesis of sweating is Yin and Yang disorder, disordered striae, resulting in perspiration abnormal. Chinese medicine by taking a single medicine, compound and acupuncture therapy, to achieve better results. In the future research, we should focus on the pathogenesis of the disease, collect more clinical cases for observation, and carry out standardized treatment.
【作者单位】：浙江省立同德医院心身二科;浙江中医药大学;
【基金】：国家自然基金项目(编号:81403502) 浙江省首届医坛新秀项目资助(编号:2013245)
【分类号】：R277.7

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