轻度认知功能损害的中医体质调查研究

发布时间：2018-07-18 07:28

【摘要】：目的:探讨上海中医药大学附属普陀临床医学院门诊及住院病人轻度认知功能损害(MCI)的好发体质类型。方法:选择98例MCI患者为病例组,另选择98例认知功能正常人群作为正常对照组;收集调查对象的一般资料、临床表现和舌脉进行分析,根据王琦等制订的9种基本中医体质类型的分类及其诊断表述依据判断中医体质类型。结果:多因素回归分析显示:(1)一般资料中,MCI组和正常对照组年龄层分布具有显著性差异(P0.001),且随年龄增长,MCI患病比例明显增高;就业情况对MCI患者具有明显影响(P0.05);性别和文化因素对MCI发病的影响并不明显(P0.05)。(2)中医体质方面,MCI患者的中医体质构成中,痰湿质占39%,其次为瘀血质、阴虚质和湿热质,分别占20%、15%和13%,其他体质如气郁质、特禀质、平和质、气虚质和阳虚质患者均较少,占MCI患者的13%;MCI组和正常对照组对比分析,9种中医体质类型均无统计学差异(P0.05)。结论:痰湿质可能为MCI的好发体质,阴虚质、瘀血质及湿热质亦为MCI的易发因素,积极改善体质类型对防治MCI具有重要作用。
[Abstract]:Objective: to investigate the prevalence of mild cognitive impairment (MCI) in outpatients and inpatients of Putuo Clinical Medical College affiliated to Shanghai University of traditional Chinese Medicine. Methods: 98 patients with MCI were selected as the case group and 98 normal persons with cognitive function as the normal control group. According to the classification and diagnostic expression of 9 basic TCM physique types established by Wang Qi et al. Results: multivariate regression analysis showed that: (1) there were significant differences in age distribution between MCI group and normal control group (P0.001), and the prevalence rate of MCI increased with age. The employment situation had obvious influence on MCI patients (P0.05), gender and culture factors had no obvious influence on the pathogenesis of MCI (P0.05). (P0.05) in TCM constitution, phlegm and dampness accounted for 39%, followed by blood stasis, yin deficiency and dampness and heat, in TCM constitution of patients with MCI, phlegm and dampness accounted for 39%, followed by blood stasis, yin deficiency and dampness and heat. Other physiques such as Qi stagnation, special, calmer, Qi deficiency and Yang deficiency were less, and there were no statistical differences in 9 TCM constitution types between MCI group and normal control group (P0.05). Conclusion: phlegm and dampness may be the predilection constitution of MCI, and Yin deficiency, blood stasis and dampness and heat are the predisposing factors of MCI. It is important to improve the physique type to prevent and treat MCI.
【作者单位】：上海中医药大学附属普陀医院中医内科;
【基金】：国家自然科学基金资助项目(81503370) 上海市第六人民医院医疗集团课题研究基金资助项目(14-LY-01) 上海市卫计委青年医师培养资助计划项目
【分类号】：R277.7

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