加味肾衰方为主治疗CKD3期脾肾阳虚、湿浊血瘀证回顾性临床研究
发布时间：2018-07-18 08:58
【摘要】：目的:通过观察肾衰方加桂枝为主多途径治疗CKD3期脾肾阳虚、湿浊血瘀证型患者的疗效情况,探讨该疗法对实验室指标及中医临床症状的影响,为进一步指导中医临床治疗实践提供依据。材料与方法:1.本次选取2015年1月-2016年12月在辽宁中医药大学附属医院肾内科病房诊断为CKD3期脾肾阳虚、湿浊血瘀证型患者共96例,依纳入标准、排除标准最终选52例纳入研究。选取采用肾衰宁片为主治疗的患者纳入对照组,共计26例;采用肾衰方加桂枝为主治疗的患者纳入治疗组,共计26例。2.两组同时给予低盐、低优质蛋白等对症治疗;降氮煎剂中药保留灌肠周五次,结肠透析治疗周两次。治疗组予中药汤剂肾衰方加桂枝,每日一剂,100ml日三次口服;对照组予肾衰宁片口服,一次5片,一日3次。两组治疗疗程二周。3.观察治疗前后两组患者的临床症状、体征及中医证候积分。比较两组患者治疗前后的血清肌酐(Scr)、尿素氮(BUN)、内生肌酐清除率(Ccr)的变化。结果:疾病疗效:治疗组总有效率为86.7%,对照组总有效率为76.7%,95%CI有重叠,无统计学差异。中医证候疗效:治疗组总有效率92.31%,对照组总有效率57.70%,95%CI无重叠,有统计学差异。结论:基础治疗结合口服肾衰方加桂枝、降氮煎剂中药保留灌肠和结肠透析治疗的三联疗法可以作为CKD3期脾肾阳虚、湿浊血瘀证型患者的临床选择,且此治疗方案能更有效改善患者的中医证候和尿素氮水平。
[Abstract]:Objective: to observe the curative effect of Shenshuai prescription plus Guizhi in treating CKD3 patients with deficiency of spleen and kidney yang, dampness and blood stasis, and to explore the effect of this therapy on laboratory indexes and clinical symptoms of TCM. To further guide the clinical treatment of traditional Chinese medicine to provide the basis. Materials and methods: 1. From January 2015 to December 2016, 96 cases of CKD3 patients with deficiency of spleen and kidney yang and dampness and turbid blood stasis were diagnosed in Department of Nephrology of affiliated Hospital of Liaoning University of traditional Chinese Medicine. 52 cases were included in the study according to inclusive criteria and exclusion criteria. A total of 26 patients treated with Shenshuai decoction plus Guizhi were included in the control group, and 26 patients were included in the treatment group with Shenshuai decoction plus Guizhi. 2. The two groups were given low salt, low quality protein and other symptomatic treatments. The treatment group was treated with Shenshuai decoction plus Guizhi, one dose of 100ml per day, three times a day, while the control group was given Shenshuaining tablets, 5 tablets once a day, 3 times a day. The two groups were treated for two weeks. The clinical symptoms, signs and TCM syndromes were observed before and after treatment. Serum creatinine (SCR), urea nitrogen (bun) and endogenous creatinine clearance (CCR) were compared before and after treatment. Results: the total effective rate was 86.7 in the treatment group and 76.7in the control group. There was no statistical difference between the two groups. The curative effect of TCM syndrome: the total effective rate of the treatment group was 92.31, the total effective rate of the control group was 57.70 and 95% CI had no overlap, there was statistical difference. Conclusion: the basic treatment combined with oral Shenshuai prescription plus Guizhi, nitrogen-reducing decoction retention enema and colon dialysis can be used as the clinical choice of CKD3 patients with deficiency of spleen and kidney yang, dampness and blood stasis. This treatment can improve TCM syndrome and urea nitrogen level more effectively.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5
本文编号：2131404
[Abstract]:Objective: to observe the curative effect of Shenshuai prescription plus Guizhi in treating CKD3 patients with deficiency of spleen and kidney yang, dampness and blood stasis, and to explore the effect of this therapy on laboratory indexes and clinical symptoms of TCM. To further guide the clinical treatment of traditional Chinese medicine to provide the basis. Materials and methods: 1. From January 2015 to December 2016, 96 cases of CKD3 patients with deficiency of spleen and kidney yang and dampness and turbid blood stasis were diagnosed in Department of Nephrology of affiliated Hospital of Liaoning University of traditional Chinese Medicine. 52 cases were included in the study according to inclusive criteria and exclusion criteria. A total of 26 patients treated with Shenshuai decoction plus Guizhi were included in the control group, and 26 patients were included in the treatment group with Shenshuai decoction plus Guizhi. 2. The two groups were given low salt, low quality protein and other symptomatic treatments. The treatment group was treated with Shenshuai decoction plus Guizhi, one dose of 100ml per day, three times a day, while the control group was given Shenshuaining tablets, 5 tablets once a day, 3 times a day. The two groups were treated for two weeks. The clinical symptoms, signs and TCM syndromes were observed before and after treatment. Serum creatinine (SCR), urea nitrogen (bun) and endogenous creatinine clearance (CCR) were compared before and after treatment. Results: the total effective rate was 86.7 in the treatment group and 76.7in the control group. There was no statistical difference between the two groups. The curative effect of TCM syndrome: the total effective rate of the treatment group was 92.31, the total effective rate of the control group was 57.70 and 95% CI had no overlap, there was statistical difference. Conclusion: the basic treatment combined with oral Shenshuai prescription plus Guizhi, nitrogen-reducing decoction retention enema and colon dialysis can be used as the clinical choice of CKD3 patients with deficiency of spleen and kidney yang, dampness and blood stasis. This treatment can improve TCM syndrome and urea nitrogen level more effectively.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5
【参考文献】
相关期刊论文 前10条
1 王银萍;陈静;王宏安;刘冰冰;孟丹丹;张守琳;;赵振昌教授从虚论治慢性肾衰经验撷菁[J];中国中医药现代远程教育;2016年19期
2 楚秀丽;余海龙;詹华奎;;叶传蕙教授多途径治疗慢性肾衰终末期患者经验拾珍[J];亚太传统医药;2016年18期
3 李智;高杨;王伟莉;;丹参多酚酸盐联合肾衰宁治疗慢性肾衰竭的疗效观察[J];中国医院用药评价与分析;2016年S1期
4 远方;赵万超;何学红;;益肾降浊化瘀方及其拆方对肾间质纤维化大鼠TNF-α及IL-8表达的影响[J];中国实验方剂学杂志;2016年04期
5 远方;赵万超;何学红;;益肾降浊化瘀方对肾间质纤维化大鼠肾组织HGF、TGF-β_1、CTGF表达的影响[J];中华中医药学刊;2016年01期
6 商俊芳;刘宝厚;魏锦慧;;刘宝厚教授从湿热辨治肾脏病的经验[J];时珍国医国药;2015年10期
7 麻志恒;钟利平;余柯娜;何立群;;海派名医童少伯论治肾脏病经验撷要[J];江苏中医药;2015年10期
8 孙劲秋;郭恩绵;;郭恩绵多途径治疗慢性肾衰竭[J];实用中医内科杂志;2015年09期
9 张正春;孙雪松;;慢性肾衰竭中医病机探讨[J];云南中医中药杂志;2015年08期
10 焦剑;;张大宁教授治疗慢性肾功能衰竭的经验[J];天津中医药;2015年06期
相关重要报纸文章 前1条
1 孙伟;纪伟;安金龙;;朱良春治慢性肾衰经验[N];中国中医药报;2014年
，本文编号：2131404
本文链接：https://www.wllwen.com/zhongyixuelunwen/2131404.html
最近更新
教材专著
