滋补肝肾法治疗老年性失眠症（肝肾阴虚型）的临床研究
发布时间：2018-07-18 11:23
【摘要】：目的:观察以滋补肝肾法为治则的滋阴安神颗粒治疗老年性失眠症(肝肾阴虚型)的临床疗效。方法:取符合病例纳入标准的患者70例,采用临床试验随机分组原则,将患者分为滋阴安神颗粒治疗组(A组),35例;百乐眠胶囊对照组(B组),35例。A组:给予滋阴安神颗粒,1袋/次,150ml/次水冲服,2次/日,午、晚饭后口服;B组:给予百乐眠胶囊,4粒/次,2次/日,午、晚饭后口服。两组均10天为一疗程,持续观察3个疗程,治疗期间停用其它相关药物。本研究以匹兹堡睡眠质量指数量表(PSQI)积分和中医证候积分作为临床疗效评定标准。结果:本研究实际入组70例,脱落及剔除病例均为0例,两组患者依从性良好。治疗3个疗程后,两组治疗后临床疗效分析、中医证候疗效、中医症候总积分、PSQI积分及总分比较,经统计处理,P0.05,说明A组疗效优于B组。治疗后两组病人中医症状和体征表象比较,A组在改善失眠、胁肋隐痛、腰膝酸软、五心烦热、颧红盗汗、舌红苔少、脉细数症状方面优于B组,经统计处理,P0.05,有差异性。结论:以滋补肝肾法为治则的滋阴安神颗粒治疗组在临床疗效、中医症候积分和PSQI积分及总分均优于百乐眠胶囊对照组,在改善失眠、胁肋隐痛、腰膝酸软、心烦、颧红盗汗、舌红苔少、脉细数等方面疗效显著,且未见不良反应及副作用。说明滋补肝肾法是治疗老年性失眠症(肝肾阴虚型)的有效方法,值得进一步研究。
[Abstract]:Objective: to observe the clinical effect of Ziyin Anshen granule (ZYANShen) on senile insomnia (deficiency of liver and kidney yin). Methods: 70 patients who met the criteria were randomly divided into two groups: group A (group A) and group A (35 cases). There were 35 cases in control group (group B). Group A: 1 bag of Ziyin Anshen granule / 150 ml / time water was taken twice a day, afternoon, after supper, group B was given 4 capsules of Baile Mian capsule once a day, midday, oral after supper. The two groups were treated with 10 days as a course of treatment, 3 courses of treatment were observed, and other related drugs were stopped during the treatment period. In this study, Pittsburgh Sleep quality Index (PSQI) score and TCM syndrome score were used as clinical evaluation criteria. Results: there were 70 cases in the study group and 0 cases in the abscission and elimination cases. The compliance of the two groups was good. After 3 courses of treatment, the clinical effect analysis, the TCM syndromes effect, the total integral of TCM symptom PSQI and the total score of PSQI were compared between the two groups, and the results showed that the curative effect of group A was better than that of group B after three courses of treatment, and the results showed that the effect of group A was better than that of group B. Comparison of symptoms and signs of traditional Chinese Medicine in two groups after treatment: group A was superior to group B in improving insomnia, loin and rib pain, sore waist and knee, five upset heat, zygomatic red night sweat, less tongue red fur, and pulse count symptom. Conclusion: the treatment group of Ziyin Anshen granule with nourishing liver and kidney as the treatment principle is superior to the control group in clinical curative effect, symptom integral of traditional Chinese medicine, PSQI integral and total score. It can improve insomnia, rib pain, sore waist and knee, upset, zygomatic red night sweat. There were no side effects and side effects in the aspects of tongue red fur, pulse count and so on. It shows that the method of nourishing liver and kidney is an effective method to treat senile insomnia (liver and kidney yin deficiency type), which is worthy of further study.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.23
本文编号：2131753
[Abstract]:Objective: to observe the clinical effect of Ziyin Anshen granule (ZYANShen) on senile insomnia (deficiency of liver and kidney yin). Methods: 70 patients who met the criteria were randomly divided into two groups: group A (group A) and group A (35 cases). There were 35 cases in control group (group B). Group A: 1 bag of Ziyin Anshen granule / 150 ml / time water was taken twice a day, afternoon, after supper, group B was given 4 capsules of Baile Mian capsule once a day, midday, oral after supper. The two groups were treated with 10 days as a course of treatment, 3 courses of treatment were observed, and other related drugs were stopped during the treatment period. In this study, Pittsburgh Sleep quality Index (PSQI) score and TCM syndrome score were used as clinical evaluation criteria. Results: there were 70 cases in the study group and 0 cases in the abscission and elimination cases. The compliance of the two groups was good. After 3 courses of treatment, the clinical effect analysis, the TCM syndromes effect, the total integral of TCM symptom PSQI and the total score of PSQI were compared between the two groups, and the results showed that the curative effect of group A was better than that of group B after three courses of treatment, and the results showed that the effect of group A was better than that of group B. Comparison of symptoms and signs of traditional Chinese Medicine in two groups after treatment: group A was superior to group B in improving insomnia, loin and rib pain, sore waist and knee, five upset heat, zygomatic red night sweat, less tongue red fur, and pulse count symptom. Conclusion: the treatment group of Ziyin Anshen granule with nourishing liver and kidney as the treatment principle is superior to the control group in clinical curative effect, symptom integral of traditional Chinese medicine, PSQI integral and total score. It can improve insomnia, rib pain, sore waist and knee, upset, zygomatic red night sweat. There were no side effects and side effects in the aspects of tongue red fur, pulse count and so on. It shows that the method of nourishing liver and kidney is an effective method to treat senile insomnia (liver and kidney yin deficiency type), which is worthy of further study.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.23
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