内外合治治疗面部皮炎（风热毒蕴证）临床疗效观察

发布时间：2018-07-22 10:54

【摘要】：目的：近年来,随着人们物质生活水平提高,现代工业技术快速发展,食物、环境污染不断加重以及激素、化妆品滥用等,面部皮炎作为一种损容性疾病,其发病率正逐年上升。其发病机理目前尚未完全清楚,但是如何有效地治愈面部皮损,达到良好提高患者生活质量、恢复患者身心健康是皮肤科临床亟待解决的重要课题。本课题旨在通过口服简化消风散联合紫草软膏及氟芬那酸丁酯软膏外用治疗面部皮炎的临床研究比较,探讨紫草软膏治疗面部皮炎的临床疗效及作用机理。方法：将符合纳入标准的88例受试者随机分为2组,每组44例。两组患者均以口服中药(简化消风散加减)为基础治疗。治疗组予以紫草软膏均匀涂擦于面部皮损处,联合基础治疗；对照组予以氟芬那酸丁酯软膏均匀涂擦于面部皮损处,联合基础治疗。两组同时治疗4周,分别在治疗当天及治疗1周、2周及4周记录患者瘙痒、红斑等主、客观临床症状及相关的不良反应,对痊愈及显效者进行随访1月。并进行统计分析,评价疗效及复发情况。结果：经4周临床观察显示：完成临床研究病例共83例,治疗组43例,对照组40例。(1)治疗组总有效率为86.1%；对照组总有效率为90.0%；两组总疗效经统计学分析,P0.05,差异无统计学意义。(2)治疗2周,两组总积分差值比较,P0.05,差异有统计学意义。(3)两组各症状积分差值比较,在干燥脱屑、紧绷不适方面,P0.05,差异有统计学意义；在红斑、丘疹、肿胀、瘙痒、灼热方面,P均0.05,差异无统计学意义。(4)治疗组复发率为20.0%,对照组为47.8%,两组复发率比较P0.05,差异有统计学意义。结论：(1)治疗组总疗效与对照组没有区别;(2)在缓解皮肤干燥脱屑、紧绷不适感方面治疗组明显优于对照组；(3)对照组治疗面部皮炎起效比治疗组快,但是远期疗效观察发现治疗组在降低复发率方面优于对照组。
[Abstract]:Objective: in recent years, with the improvement of people's living standard, the rapid development of modern industrial technology, the worsening of food and environmental pollution, and the abuse of hormones and cosmetics, facial dermatitis is a kind of capacitive disease. Its incidence is increasing year by year. Its pathogenesis is not completely clear, but how to effectively cure facial lesions, achieve a good quality of life of patients, recovery of patients' physical and mental health is an important subject to be resolved in dermatology clinic. The purpose of this study was to compare the clinical effects and mechanism of oral simplified Xiaofeng Powder combined with Shikchow ointment and flurfenac butyrate ointment in the treatment of facial dermatitis. Methods: 88 subjects who met the inclusion criteria were randomly divided into 2 groups with 44 cases in each group. Both groups were treated with oral Chinese medicine (simplified Xiaofeng Powder plus or minus) as the basic treatment. The treatment group was evenly applied to the facial lesions and combined with basic treatment, while the control group was given flufenac butyrate ointment evenly applied to the facial lesions, combined with basic treatment. Patients with itching, erythema and other objective clinical symptoms and related adverse reactions were recorded on the day of treatment and 1 week, 2 weeks and 4 weeks of treatment respectively. The patients were followed up for 1 month. Statistical analysis was carried out to evaluate the curative effect and recurrence. Results: after 4 weeks of clinical observation, 83 cases were completed, 43 cases in the treatment group and 40 cases in the control group. (1) the total effective rate of the treatment group was 86.1, the total effective rate of the control group was 90.0%, and the total effective rate of the control group was 90.0%. There was no significant difference in the total curative effect between the two groups by statistical analysis (P 0.05). (2) after 2 weeks of treatment, the difference between the two groups was statistically significant (P 0.05). (3) the difference between the two groups was statistically significant. There was no significant difference in the aspects of erythema, papules, swelling, pruritus and burning (P 0.05). (4) the recurrence rate was 20.0% in the treatment group and 47.8% in the control group, and the difference was significant between the two groups (P 0.05). Conclusion: (1) the total curative effect of the treatment group is not different from that of the control group, (2) the treatment group is superior to the control group in relieving the dry skin desquamation and tense discomfort, (3) the treatment of facial dermatitis in the control group is faster than that in the treatment group. But long-term observation showed that the treatment group was superior to the control group in reducing recurrence rate.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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