辛开苦降方干预寒热错杂型功能性消化不良患者精神心理状态的临床研究
发布时间：2018-07-25 10:37
【摘要】：研究目的：1.通过采用Zung氏焦虑自评量表(SAS)及Zung氏抑郁自评量表(SDS)对寒热错杂型功能性消化不良患者的精神心理状态进行评定。2.观察辛开苦降方对寒热错杂型功能性消化不良患者精神心理状态的干预作用。研究方法：将符合纳入标准的105例功能性消化不良患者依据2：1的优效性临床试验原则随机分为两组,治疗组70例,对照组35例。治疗组给予辛开苦降方免煎颗粒(150m1/次,2次/日),对照组给予炒大米免煎颗粒(150m1/次,2次/日)。疗程为4周。在治疗前以及治疗4周后分别进行精神心理状态的评价、临床症状的评分,比较治疗前后功能性消化不良患者以及合并异常精神心理状态患者的精神心理状态变化情况。所有数据用SPSS19.0软件进行统计分析。研究结果：1.本研究的105例寒热错杂型FD患者,对照组脱落3例,实际分析讨论病例102例,平均年龄47.05±11.75岁；其中合并异常精神心理状态的患者为52例,占本试验总人数的50.9%,平均年龄为41.85±6.32岁。功能性消化不良合并异常精神心理状态患者中,30-39岁年龄段发病率最高,为21例。2.研究的105例功能性消化不良患者中,男女比例为1：1.56,女性多于男性。52例功能性消化不良合并异常精神心理状态的患者中,男女比例为1：3.07,女性多于男性。3.研究的102例功能性消化不良患者中,存在焦虑状态的患者有48例,存在抑郁状态的患者有7例,同时存在焦虑和抑郁状态的患者有3例。4.功能性消化不良患者焦虑、抑郁评分与临床症状积分均呈正相关。5.两组功能性消化不良患者经治疗后,临床症状积分均下降,经检验,治疗组P值0.01,具有显著性差异；对照组P值0.05,具有统计学差异性,表明治疗药与安慰剂均能改善患者的临床症状,并且治疗组的疗效更加显著。6.对于寒热错杂型功能性消化不良患者,两组药物都具有改善其精神心理状态的作用,治疗组明显优于对照组,表明辛开苦降方对功能性消化不良患者的精神心理状态有干预作用,且能有效的改善功能性消化不良患者的精神心理状态。7.对于两组中存在异常精神心理状态的功能性消化不良患者,经治疗后,SAS、SDS评分均较前降低,治疗组患者的评分较对照组明显降低,表明辛开苦降方能有效改善功能性消化不良合并异常精神心理状态患者的焦虑、抑郁情绪。8.52例功能性消化不良合并异常精神心理状态患者的焦虑、抑郁情绪改善情况明显优于102例功能性消化不良患者结论：1.寒热错杂型功能性消化不良患者中异常精神心理状态的发病率为50.9%,合并异常精神心理状态的患者中女性发病率高于男性,以30-39岁年龄段发病率最高。2.功能性消化不良患者存在精神心理障碍,且患者焦虑、抑郁评分与临床症状呈正相关,两者相互作用,相互影响。3.辛开苦降方可以有效的缓解寒热错杂型功能性消化不良症状,同时能调节功能性消化不良患者以及合并异常精神心理状态患者的焦虑、抑郁情绪。4.辛开苦降方能更好的改善寒热错杂型功能性消化不良合并异常精神心理状态患者的焦虑、抑郁情绪。
[Abstract]:Objective: 1. through the use of Zung's anxiety self rating scale (SAS) and Zung's depressive self rating scale (SDS), the mental state of patients with dysfunctional dyspepsia of cold and heat is evaluated by.2.. The intervention effect of Xin Kai bittern on the mental state of patients with dysfunctional dyspepsia of cold and heat type of dyspepsia will be observed. The 105 patients with functional dyspepsia were randomly divided into two groups according to the principle of 2:1's optimal clinical trials, 70 cases in the treatment group and 35 in the control group. The treatment group was given a free Decoction granule (150m1/ times, 2 times), and the control group was given the fried rice free granule (150m1 / times, 2 times / day). The treatment course was 4 weeks. Before treatment and 4 treatment, the treatment group was treated for 4 weeks. The mental state of the psycho state, the score of the clinical symptoms, the mental state changes of the patients with functional dyspepsia before and after treatment and the patients with abnormal mental state were compared. All the data were analyzed by SPSS19.0 software. The results of the study were: 105 cases of cold and heat disorder type FD patients in 1. studies, In 3 cases, 102 cases were analyzed and discussed. The average age was 47.05 + 11.75 years old. The patients with abnormal mental state were 52, accounting for 50.9% of the total number of the test, the average age was 41.85 + 6.32 years old. Among the patients with functional dyspepsia and abnormal mental state, the incidence of 30-39 year old was the highest, and 21 cases.2.. Among the 105 patients with functional dyspepsia, the proportion of men and women was 1:1.56, women were more than male.52 cases with functional dyspepsia and abnormal psycho mental state, the proportion of men and women was 1:3.07, and that of 102 cases of functional dyspepsia was more than that of male.3.. There were 48 cases of depression and depression in patients with anxiety. There were 7 patients in the state, 3 patients with.4. functional dyspepsia were anxious, and the score of depression was positively correlated with the score of clinical symptoms in the.5. two groups of functional dyspepsia. After treatment, the clinical symptom scores were all decreased, and the P value of the treatment group was 0.01, with a significant difference, and the P value of the control group. 0.05, with statistical difference, it shows that both the treatment and the placebo can improve the clinical symptoms of the patients, and the curative effect of the treatment group is more significant.6. for patients with dysfunctional dyspepsia, the two groups have the effect of improving their mental state, and the treatment group is obviously superior to the control group. The mental state of the patients with sexual dyspepsia had an intervention effect, and the mental state of the patients with functional dyspepsia could be effectively improved.7. for the patients with functional dyspepsia with abnormal mental state in the two groups. After treatment, the scores of SAS and SDS were lower than those in the former, and the scores of the patients in the treatment group were significantly lower than those in the control group. The results showed that Simon chicoozi could effectively improve the anxiety of patients with functional dyspepsia and abnormal psycho mental state, depression in.8.52 cases with functional dyspepsia and abnormal mental state, and the improvement of depression was obviously better than that of 102 patients with functional dyspepsia: 1. The incidence of abnormal mental state was 50.9% in the poor patients. The incidence of women in the patients with abnormal psycho mental state was higher than that of men. There were mental and psychological disorders in the patients with the highest incidence of.2. functional dyspepsia at the age of 30-39 years, and the anxiety of the patients was positively correlated with the clinical symptoms, and the interaction between them, Mutual influence.3. symplectic and bitter descending prescription can effectively alleviate the symptoms of cold and heat disorder functional dyspepsia, and can adjust the anxiety of patients with functional dyspepsia and patients with abnormal mental state, and the depression of depression.4. can better improve the cold and heat mixed dysfunctional dyspepsia and abnormal psychosocial condition. State of the patient's anxiety, depression.
【学位授予单位】：中国中医科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
[Abstract]:Objective: 1. through the use of Zung's anxiety self rating scale (SAS) and Zung's depressive self rating scale (SDS), the mental state of patients with dysfunctional dyspepsia of cold and heat is evaluated by.2.. The intervention effect of Xin Kai bittern on the mental state of patients with dysfunctional dyspepsia of cold and heat type of dyspepsia will be observed. The 105 patients with functional dyspepsia were randomly divided into two groups according to the principle of 2:1's optimal clinical trials, 70 cases in the treatment group and 35 in the control group. The treatment group was given a free Decoction granule (150m1/ times, 2 times), and the control group was given the fried rice free granule (150m1 / times, 2 times / day). The treatment course was 4 weeks. Before treatment and 4 treatment, the treatment group was treated for 4 weeks. The mental state of the psycho state, the score of the clinical symptoms, the mental state changes of the patients with functional dyspepsia before and after treatment and the patients with abnormal mental state were compared. All the data were analyzed by SPSS19.0 software. The results of the study were: 105 cases of cold and heat disorder type FD patients in 1. studies, In 3 cases, 102 cases were analyzed and discussed. The average age was 47.05 + 11.75 years old. The patients with abnormal mental state were 52, accounting for 50.9% of the total number of the test, the average age was 41.85 + 6.32 years old. Among the patients with functional dyspepsia and abnormal mental state, the incidence of 30-39 year old was the highest, and 21 cases.2.. Among the 105 patients with functional dyspepsia, the proportion of men and women was 1:1.56, women were more than male.52 cases with functional dyspepsia and abnormal psycho mental state, the proportion of men and women was 1:3.07, and that of 102 cases of functional dyspepsia was more than that of male.3.. There were 48 cases of depression and depression in patients with anxiety. There were 7 patients in the state, 3 patients with.4. functional dyspepsia were anxious, and the score of depression was positively correlated with the score of clinical symptoms in the.5. two groups of functional dyspepsia. After treatment, the clinical symptom scores were all decreased, and the P value of the treatment group was 0.01, with a significant difference, and the P value of the control group. 0.05, with statistical difference, it shows that both the treatment and the placebo can improve the clinical symptoms of the patients, and the curative effect of the treatment group is more significant.6. for patients with dysfunctional dyspepsia, the two groups have the effect of improving their mental state, and the treatment group is obviously superior to the control group. The mental state of the patients with sexual dyspepsia had an intervention effect, and the mental state of the patients with functional dyspepsia could be effectively improved.7. for the patients with functional dyspepsia with abnormal mental state in the two groups. After treatment, the scores of SAS and SDS were lower than those in the former, and the scores of the patients in the treatment group were significantly lower than those in the control group. The results showed that Simon chicoozi could effectively improve the anxiety of patients with functional dyspepsia and abnormal psycho mental state, depression in.8.52 cases with functional dyspepsia and abnormal mental state, and the improvement of depression was obviously better than that of 102 patients with functional dyspepsia: 1. The incidence of abnormal mental state was 50.9% in the poor patients. The incidence of women in the patients with abnormal psycho mental state was higher than that of men. There were mental and psychological disorders in the patients with the highest incidence of.2. functional dyspepsia at the age of 30-39 years, and the anxiety of the patients was positively correlated with the clinical symptoms, and the interaction between them, Mutual influence.3. symplectic and bitter descending prescription can effectively alleviate the symptoms of cold and heat disorder functional dyspepsia, and can adjust the anxiety of patients with functional dyspepsia and patients with abnormal mental state, and the depression of depression.4. can better improve the cold and heat mixed dysfunctional dyspepsia and abnormal psychosocial condition. State of the patient's anxiety, depression.
【学位授予单位】：中国中医科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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