解毒化瘀通腑方对酒精性肝硬化患者内毒素及炎性因子的影响

发布时间：2018-07-29 18:25

【摘要】：目的:观察解毒化瘀通腑方对酒精性肝硬化患者内毒素及炎性因子的影响。方法:将78例酒精性肝硬化患者随机分为治疗组和对照组,每组39例,在西医综合治疗的基础上,治疗组给予解毒化瘀通腑方口服,每日2次,疗程为4周,记录两组患者治疗前后生化指标及内毒素、炎性因子[肿瘤坏死因子α(TNF-α)、白介素-1(IL-1)、白介素-6(IL-6)]水平变化。结果:治疗组好转率为89.7%,对照组为74.3%,两组差异有统计学意义(P0.05);两组治疗后肝功能及凝血酶原活动度较治疗前都有改善,其中天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、总胆红素(TBil)、凝血酶原活动度(PTA)治疗组较对照组改善更为显著(P0.05);两组治疗后血清内毒素及炎性因子水平较治疗前明显下降(P0.05),治疗组较对照组改善更为显著(P0.05)。结论:解毒化瘀通腑方治疗酒精性肝硬化有较好的临床疗效,其作用机制可能为通过降低血清内毒素水平,从而减少炎性因子的释放,起到肝脏保护作用。
[Abstract]:Objective: to observe the effect of jiedu Huayu decoction on endotoxin and inflammatory factors in patients with alcoholic cirrhosis. Methods: 78 patients with alcoholic cirrhosis were randomly divided into treatment group (n = 39) and control group (n = 39). The changes of biochemical index, endotoxin, inflammatory factor (TNF- 伪), interleukin-1 (IL-1) and interleukin-6 (IL-6) were recorded before and after treatment. Results: the improvement rate of the treatment group was 89.7 and that of the control group was 74.3, the difference between the two groups was statistically significant (P0.05), the liver function and prothrombin activity of the two groups were improved after treatment. The prothrombin activity of aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), total bilirubin (TBil), prothrombin activity in the (PTA) group was significantly improved than that in the control group (P0.05); the levels of serum endotoxin and inflammatory factors in the two groups after treatment were significantly lower than those before treatment (P0.05). Decreased (P0.05), the treatment group than the control group more significant improvement (P0.05). Conclusion: jiedu Huayu Tongfu recipe has good clinical effect on alcoholic cirrhosis, and its mechanism may be to reduce the release of inflammatory factors and protect the liver by reducing the level of serum endotoxin.
【作者单位】：河南中医药大学第一附属医院;
【基金】：国家自然科学基金(联合基金)项目(No.U1504825)~~
【分类号】：R259

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