多囊卵巢综合征痰湿证患者糖代谢的临床研究

发布时间：2018-08-02 18:34

【摘要】：目的:探讨多囊卵巢综合征(PCOS)痰湿证患者的糖代谢特征。方法:选择临床科研信息一体化平台采集的多囊卵巢综合征病例数据110例,其中痰湿证组60例,非痰湿证组50例;分析、比较各组的糖代谢特征。结果:1PCOS痰湿组体质量指数(BMI)、腰臀比显著大于PCOS非痰湿组(P0.05),睾酮水平显著高于非痰湿组(P0.05);两组间黄体生成素(LH)、卵泡刺激素(FSH)和LH与FSH比值差异无统计学意义(P0.05);2糖代谢方面:痰湿证组空腹葡萄糖、糖耐量30 min葡萄糖、60 min葡萄糖、120 min葡萄糖和葡萄糖曲线下面积均显著高于非痰湿证组(P0.05),两组180 min葡萄糖水平无统计学意义(P0.05);痰湿证组空腹胰岛素、胰岛素释放试验30 min胰岛素、60 min胰岛素、120 min胰岛素和胰岛素曲线下面积均显著高于非痰湿证组(P0.05);两组180 min胰岛素水平无统计学意义(P0.05);痰湿证组胰岛素抵抗指数显著大于非痰湿证组(P0.05);3 Pcos痰湿证患者糖耐量异常的发生率为33.33%。结论:PCOS痰湿证患者具有高BMI、WHR及高睾酮水平,以腹型肥胖为主;表现出明显的糖代谢异常伴胰岛素抵抗指数升高;痰湿证型PCOS患者糖耐量异常比例较高。临床上应重视对PCOS患者进行糖耐量试验和胰岛素释放试验的检测,积极预防远期并发症的发生。
[Abstract]:Objective: To investigate the characteristics of glucose metabolism in patients with phlegm dampness syndrome of polycystic ovary syndrome (PCOS). Methods: 110 cases of polycystic ovary syndrome were collected from the information integration platform of clinical scientific research, including 60 cases of phlegm damp syndrome group and 50 cases of non phlegm damp syndrome group. Analysis was made to compare the characteristics of glucose metabolism in each group. Results: 1PCOS phlegm dampness group mass index (BMI), waist. The hip ratio was significantly greater than that of the PCOS non phlegm damp group (P0.05), and the testosterone level was significantly higher than that in the non phlegm damp group (P0.05), and there was no significant difference between the two groups of luteinizing hormone (LH), follicle stimulating hormone (FSH) and LH and FSH (P0.05), and the 2 glycometabolism: phlegm damp syndrome group fasting glucosamine, glucose tolerance 30 min glucose, 60 min glucose, 120 min glucose and glucose The area under the curve was significantly higher than that of the non phlegm damp syndrome group (P0.05), and there was no significant difference in the level of 180 min glucose in the two groups (P0.05). The area of the fasting insulin in the phlegm damp syndrome group, the insulin release test 30 min insulin, the 60 min insulin, the 120 min insulin and the insulin curve were significantly higher than the non phlegm damp syndrome group (P0.05), and the two group 180 min insulin level. There was no statistical significance (P0.05); the insulin resistance index in the phlegm damp syndrome group was significantly greater than that of the non phlegm damp syndrome group (P0.05); the incidence of glucose tolerance abnormality in 3 Pcos phlegm damp syndrome patients was 33.33%. conclusion: the patients with PCOS phlegm damp syndrome had high BMI, WHR and high testosterone level, mainly with abdominal obesity, and showed obvious glucose metabolism abnormality with the increase of insulin resistance index. The proportion of abnormal glucose tolerance in PCOS patients with phlegm dampness syndrome is high. It should be paid more attention to the test of glucose tolerance test and insulin release test in patients with PCOS, and actively prevent the occurrence of long-term complications.
【作者单位】：黑龙江中医药大学;黑龙江中医药大学附属第一医院妇产科;
【基金】：全国名老中医药专家侯丽辉传承工作室项目(2014-9-10) 国家中医药管理局国家中医临床研究基地业务建设科研专项项目(JDZX2012039) 国家中医药行业科研专项项目(201207001)
【分类号】：R271.9

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