四合一方对胃癌前病变患者的临床干预

发布时间：2018-08-08 19:05

【摘要】：目的:本次研究通过观察四合一方对胃癌前病变的治疗作用和临床症状的改善情况,探讨四合一方的可能治疗机制,为中医对胃癌前病变的治疗探索新的治疗方法和思路。方法:选择符合纳入标准的胃癌前病变患者62例,按中医辨证分型纳入肝胃不和证、脾胃虚弱证、脾胃湿热证、胃络瘀血证治疗;使用四合一方辨证加减,服药2个疗程,每个疗程3个月。采用自身前后对照分析,观察疗效时观察各种证型治疗前后的中医症候积分,四种证型组间的疗效,治疗前后Hp阳性例数,治疗前后病理检查的萎缩、肠上皮化生、异型增生。结果:1.各种证型治疗前后中医症候积分比较,治疗后积分比治疗前积分明显下降,差异有统计学意义(P0.05)。2.四种证型中医症候疗效组间比较,差异无统计学意义(P0.05)。3.治疗前后Hp阳性比较,治疗后Hp阳性比治疗前下降,差异有统计学意义(P0.05)。4.治疗前后病理检查比较,治疗后萎缩、肠化、异型增生比治疗前改善,差异有统计学意义(P0.05)。结论:1.四合一方能灵活运用于不同的胃癌前病变证型并能改善患者临床症状。2.四合一方能逆转胃癌前病变,减缓胃癌前病变的进展。
[Abstract]:Objective: to explore the possible therapeutic mechanism of Siyinfang in the treatment of precancerous lesions of gastric cancer by observing the therapeutic effect and the improvement of clinical symptoms of SYF in order to explore a new treatment method and train of thought for the treatment of precancerous lesions of gastric cancer in traditional Chinese medicine (TCM). Methods: Sixty-two patients with gastric precancerous lesions who met the inclusive criteria were selected to be treated with syndrome of disharmony of liver and stomach, deficiency of spleen and stomach, dampness and heat of spleen and stomach, and blood stasis of stomach according to syndrome differentiation of TCM. Each course of treatment was 3 months. The syndromes of different syndromes before and after treatment, the curative effect among the four syndromes groups, the number of HP positive cases before and after treatment, the atrophy of pathological examination before and after treatment, intestinal metaplasia and dysplasia were observed. The result is 1: 1. All kinds of syndrome before and after treatment of traditional Chinese medicine syndrome score comparison, after treatment the integral scores were significantly lower than before treatment, the difference was statistically significant (P0.05). 2. There was no significant difference between the four syndromes of TCM syndromes (P0.05). 3. HP positive comparison before and after treatment, HP positive after treatment than before treatment, the difference was statistically significant (P0.05). 4. Before and after treatment pathological examination comparison, after treatment atrophy, intestinal metaplasia, dysplasia than before treatment improved, the difference was statistically significant (P0.05). Conclusion 1. The four-in-one formula can be used flexibly in different types of gastric precancerous lesions and can improve the clinical symptoms. 2. 2. The four-in-one prescription can reverse gastric precancerous lesion and slow down the progress of gastric precancerous lesion.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R273

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