调补肝肾汤对H型高血压（阴虚阳亢证）Hey干预的临床研究

发布时间：2018-08-08 16:57

【摘要】：目的:观察调补肝肾汤对H型高血压(阴虚阳亢证)患者降低血清同型半胱氨酸水平、降低血压、改善中医证候等方面的临床效果和安全性指标。方法:选择60例符和纳入标准的H型高血压病(阴虚阳亢证)患者,随机分为对照组与治疗组,每组各30例,两组患者的年龄、性别、疾病严重程度等无统计学差异。对照组采取常规西药治疗,即马来酸依那普利叶酸片10mg/0.8mg,一日一次。治疗组口服马来酸依那普利叶酸片10mg/0.8mg,一日一次,同时口服调补肝肾汤,一日三次。治疗周期为30天,于治疗前后观察患者血清同型半胱氨酸水平、血压及中医证候指标,观察结果运用χ2检验,配对样本运用t检验进行统计分析。结果:1.血清同型半胱氨酸浓度比较,两组在治疗前血清同型半胱氨酸浓度无显著性差异;治疗后对照组血清同型半胱氨酸浓度为22.19±3.56umol/L,实验组血清同型半胱氨酸浓度为18.83±2.38 umol/L,实验组和对照组间比较P0.01,有极显著差异,实验组降低血清同型半胱氨酸的效果显著优于对照组。2.治疗总有效率:对照组总有效率为56.67%,治疗组总有效率为86.67%,两组组间比较P0.05,有显著差异,治疗组总有效率高于对照组;两组治疗前血压对比P0.05,差异无统计学意义;两组治疗后血压对比P0.05,有显著差异;3.两组治疗前后中医证候改善指标比较,P0.05,有显著差异,治疗组对中医证候改善优于对照组;4.治疗组和对照组患者在治疗前后均未出现不良反应,安全观察指标比较无明显差异。结论:调补肝肾汤治疗H型高血压(阴虚阳亢证)安全有效,能明显改善患者中医证候,能同时降低H型高血压患者血压和血清同型半胱氨酸水平,具有很高的临床应用价值和应用前景。
[Abstract]:Objective: to observe the clinical effect and safety index of Tiaoguanshen decoction in reducing serum homocysteine level, lowering blood pressure and improving TCM syndromes in patients with H type hypertension (yin deficiency and yang hyperactivity syndrome). Methods: sixty patients with H type hypertension (yin deficiency and yang hyperactivity) were randomly divided into control group and treatment group with 30 cases in each group. There was no significant difference in age, sex and severity of disease between the two groups. The control group was treated with routine western medicine, that is, 10 mg / 0.8 mg folic acid tablets of enalapril maleate, once a day. In the treatment group, 10 mg / 0.8 mg folic acid tablets of enalapril maleate were given orally, once a day, and oral tonifying liver and kidney decoction, three times a day. The treatment period was 30 days. The serum homocysteine level, blood pressure and TCM syndromes were observed before and after treatment. The results were analyzed by 蠂 2 test and t test. The result is 1: 1. There was no significant difference in serum homocysteine concentration between the two groups before treatment. After treatment, the serum homocysteine concentration in the control group was 22.19 卤3.56 umol/ L, the serum homocysteine concentration in the experimental group was 18.83 卤2.38 umol / L, the difference between the experimental group and the control group was very significant (P 0.01). The effect of reducing serum homocysteine in the experimental group was significantly higher than that in the control group (.2.). The total effective rate of treatment: the total effective rate of the control group was 56.67 and the total effective rate of the treatment group was 86.67, the difference between the two groups was significant (P0.05), the total effective rate of the treatment group was higher than that of the control group, the blood pressure of the two groups was higher than that of the control group before treatment, the difference was not statistically significant. There was a significant difference in blood pressure between the two groups after treatment (P 0.05). There was significant difference between the two groups before and after treatment. The improvement of TCM syndrome in the treatment group was better than that in the control group (P 0.05). There were no adverse reactions before and after treatment in the treatment group and the control group, and there was no significant difference in the safety observation index between the treatment group and the control group. Conclusion: Tiaoguanshen decoction is safe and effective in treating H type hypertension (Yin deficiency and yang hyperactivity syndrome), it can obviously improve the syndrome of traditional Chinese medicine, decrease blood pressure and serum homocysteine level in patients with H type hypertension at the same time. It has high clinical application value and application prospect.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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