冠心丹参滴丸对慢性稳定型心绞痛血瘀证患者血瘀证计分及血清相关黏附因子水平的影响
发布时间：2018-08-08 16:52
【摘要】：目的观察冠心丹参滴丸治疗慢性稳定型心绞痛血瘀证患者临床疗效。方法采取随机、双盲、安慰剂对照的方法将240例慢性稳定型心绞痛血瘀证患者分为治疗组与对照组各120例。治疗组在西药常规治疗基础上给予冠心丹参滴丸口服,对照组在西药常规治疗基础上给予安慰剂口服,均每次0.4 g,每日3次,连续1个月。观察治疗前后患者的中医主症计分、血瘀证计分及血清可溶性细胞间黏附分子1(s ICAM-1)、可溶性血管细胞间黏附分子1(s VCAM-1)水平变化,并观察不良反应。结果治疗组纳入统计108例,对照组纳入统计104例。两组患者治疗后中医主症计分、血瘀证计分、血清s VCAM-1及s ICAM-1水平均较治疗前明显降低(P0.05);治疗组治疗后血瘀证计分、血清s VCAM-1及s ICAM-1水平治疗后均较对照降低明显(P0.05)。治疗期间两组均未出现严重的不良反应。结论冠心丹参滴丸可有效的降低慢性稳定型心绞痛血瘀证患者血瘀证计分及血清s ICAM-1、s VCAM-1水平。
[Abstract]:Objective to observe the clinical effect of Guanxin Danshen dropping pill on chronic stable angina pectoris with blood stasis syndrome. Methods 240 patients with chronic stable angina pectoris and blood stasis syndrome were randomly divided into treatment group (n = 120) and control group (n = 120). The treatment group was treated with Guanxin Danshen dropping pills on the basis of routine western medicine, while the control group was given placebo on the basis of routine western medicine treatment, three times a day for 1 month. The scores of main symptoms, blood stasis syndrome, serum soluble intercellular adhesion molecule 1 (s ICAM-1) and soluble vascular intercellular adhesion molecule 1 (s VCAM-1) were observed before and after treatment, and adverse reactions were observed. Results 108 cases were included in the treatment group and 104 cases in the control group. After treatment, the scores of TCM main symptoms, blood stasis syndrome, serum s VCAM-1 and s ICAM-1 in the two groups were significantly lower than those before treatment (P0.05); after treatment, the scores of blood stasis syndrome, serum s VCAM-1 and s ICAM-1 in the treatment group were significantly lower than those in the control group (P0.05). There were no serious adverse reactions in both groups during the treatment. Conclusion Guanxin Danshen dropping pills can effectively reduce the score of blood stasis syndrome and the level of serum sICAM-1s VCAM-1 in patients with chronic stable angina pectoris with blood stasis syndrome.
【作者单位】： 中国中医科学院西苑医院;北京中医药大学;
【基金】：国家科技重大专项(2009ZX09502-031)
【分类号】：R259
[Abstract]:Objective to observe the clinical effect of Guanxin Danshen dropping pill on chronic stable angina pectoris with blood stasis syndrome. Methods 240 patients with chronic stable angina pectoris and blood stasis syndrome were randomly divided into treatment group (n = 120) and control group (n = 120). The treatment group was treated with Guanxin Danshen dropping pills on the basis of routine western medicine, while the control group was given placebo on the basis of routine western medicine treatment, three times a day for 1 month. The scores of main symptoms, blood stasis syndrome, serum soluble intercellular adhesion molecule 1 (s ICAM-1) and soluble vascular intercellular adhesion molecule 1 (s VCAM-1) were observed before and after treatment, and adverse reactions were observed. Results 108 cases were included in the treatment group and 104 cases in the control group. After treatment, the scores of TCM main symptoms, blood stasis syndrome, serum s VCAM-1 and s ICAM-1 in the two groups were significantly lower than those before treatment (P0.05); after treatment, the scores of blood stasis syndrome, serum s VCAM-1 and s ICAM-1 in the treatment group were significantly lower than those in the control group (P0.05). There were no serious adverse reactions in both groups during the treatment. Conclusion Guanxin Danshen dropping pills can effectively reduce the score of blood stasis syndrome and the level of serum sICAM-1s VCAM-1 in patients with chronic stable angina pectoris with blood stasis syndrome.
【作者单位】： 中国中医科学院西苑医院;北京中医药大学;
【基金】：国家科技重大专项(2009ZX09502-031)
【分类号】：R259
【参考文献】
相关期刊论文 前10条
1 杨巧宁;谷丰;高铸烨;张庆翔;时莉晓;李立志;史大卓;;冠心丹参滴丸治疗冠心病随机对照试验的系统评价[J];中国实验方剂学杂志;2014年16期
2 张琳琳;狄长华;陈风;;冠心丹参滴丸对冠心病心绞痛患者血清C反应蛋白及基质金属蛋白酶-9的影响[J];实用临床医药杂志;2013年15期
3 李艳;刘卫星;;血浆sICAM-1、sVCAM-1含量与冠心病气虚血瘀证的相关性研究[J];山东中医药大学学报;2012年06期
4 付长庚;高铸烨;王培利;王承龙;徐浩;史大卓;陈可冀;;冠心病血瘀证诊断标准研究[J];中国中西医结合杂志;2012年09期
5 张青;;冠心丹参滴丸治疗冠心病心绞痛疗效观察[J];中外医疗;2012年15期
6 杨宝元;李继安;董印宏;冯伟;张磊;;冠心病气虚血瘀证血管内皮细胞功能失调相关性研究[J];江苏中医药;2011年08期
7 谭R，
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