加味二陈汤对稳定型心绞痛（痰浊内阻）伴高Hcy血症的临床观察

发布时间：2018-08-08 20:06

【摘要】：目的:应用加味二陈汤治疗冠心病稳定型心绞痛(痰浊内阻型)患者,通过治疗前后的对比,观察加味二陈汤对患者心肌缺血总负荷及血清同型半胱氨酸的影响。方法:本次临床观察的42例患者来自黑龙江中医药大学附属第一医院门诊部,现代医学诊断为冠心病稳定型心绞痛,中医诊断为胸痹痰浊内阻型,对患者给以加味二陈汤,治疗时间为4周,观察治疗前后患者中医证候积分、动态心电心肌缺血总负荷、血清同型半胱氨酸(Hcy)、硝酸甘油使用量的变化,采用SPSS19.0进行统计学分析。结果:1.中医证候总积分及有效率:治疗后患者的中医证候总积分较治疗前患者的总积分降低,其差异具有统计学意义(P0.05)。2.24小时心肌缺血总负荷:治疗后患者的心肌缺血总负荷较治疗前患者的心肌缺血总负荷降低,其差异具有统计学意义(p0.05)。3.血清同型半胱氨酸比较:治疗后患者的血清同型半胱氨酸较治疗前降低,其差异具有统计学意义(P0.05)。4.硝酸甘油使用情况:硝酸甘油停减率83.33%。5.总有效率:患者经治疗后,显效12例,有效26例,总有效率为90.48%。结论:1.加味二陈汤可以降低冠心病心绞痛痰浊内阻型患者的中医证候总积分,改善其中医证候。2.加味二陈汤可以降低冠心病心绞痛痰浊内阻型患者的24小时动态心电图心肌缺血总负荷。3.加味二陈汤可以降低冠心病心绞痛痰浊内阻型患者的血清同型半胱氨酸水平。
[Abstract]:Objective: To observe the effect of Jiawei two Chen Decoction on the total load of myocardial ischemia and the serum homocysteine in patients with stable angina pectoris (turbid phlegm resistance type) of coronary heart disease (turbid phlegm resistance type) before and after treatment. Methods: 42 patients from this clinical observation came from the outpatient department of the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine, Modern medicine was diagnosed as stable angina pectoris of coronary heart disease. Chinese medicine was diagnosed as internal obstruction of chest obstruction and phlegm turbidity. The treatment time was 4 weeks for patients. The score of TCM syndrome, dynamic myocardial ischemia total load, serum homocysteine (Hcy), use of nitroglycerin before and after treatment were observed before and after treatment, and SPSS19.0 was adopted. Results: total score and efficiency of 1. TCM syndromes: the total integral of TCM syndrome after treatment was lower than that of the patients before treatment. The difference was statistically significant (P0.05).2.24 hour total load of myocardial ischemia: the total load of myocardial ischemia in patients after treatment was lower than that of the patients before treatment, and the difference between the total load and the total load of myocardial ischemia was lower than that of the patients before treatment. Statistical significance (P0.05).3. serum homocysteine comparison: the serum homocysteine of patients after treatment was lower than before treatment, the difference was statistically significant (P0.05).4. nitroglycerin use situation: Nitroglycerin reduction rate 83.33%.5. total efficiency: Patients after treatment, 12 cases, effective 26 cases, the total effective rate of 90.48%. knot Theory: 1. flavored two Chen decoction can reduce the total score of TCM syndrome in patients with angina pectoris of angina pectoris, improvement of TCM syndrome.2. plus flavour two Chen Tang can reduce the total load of myocardial ischemia in 24 hour dynamic electrocardiogram of patients with coronary heart disease and angina pectoris,.3. Jiawei Er Chen decoction can reduce the phlegm resistance of angina pectoris of coronary heart disease The serum level of homocysteine in the patient.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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