基于广义估计方程的缺血性中风病中医证候要素动态变化与NIHSS评分变化纵向相关性分析

发布时间：2018-08-09 07:08

【摘要】：目的:探讨缺血性中风病中医证候要素动态变化与NIHSS评分之间的关系。方法:以379例缺血性中风病临床数据为基础,在入院时、3、14、28、90 d分别采集《中风病辨证诊断标准》中风、火、痰、瘀、气虚、阴虚阳亢6个证候要素的评分和《美国国立卫生院卒中量表》(NIHSS)评分,运用广义估计方程分析其相关性。结果:NIHSS评分与各证候要素评分变化有相同的变化规律,均随时间变化呈下降趋势;NIHSS评分的改变对证候要素风、火热、痰、气虚、阴虚阳亢评分的改变有影响,NIHSS评分每增加或减少1分,相应证候要素评分分别增加或减少0.403分、0.224分、0.355分、0.376分、0.157分。结论:缺血性中风病的NIHSS评分变化在不同时点与多个不同证候要素评分的变化相关,其相关程度不同。
[Abstract]:Objective: to investigate the relationship between dynamic changes of TCM syndromes and NIHSS score in ischemic stroke. Methods: based on the clinical data of 379 patients with ischemic stroke, the diagnosis criteria of apoplexy syndrome were collected on the day of admission, including stroke, fire, phlegm, blood stasis and deficiency of qi. The scores of six syndromes of yin deficiency and yang hyperactivity and the (NIHSS) score of the National Institutes of Health Stroke scale were used to analyze their correlation with the generalized estimation equation. Results the changes of the score of proportion NIHSS were the same as those of the scores of every syndromes. The change of the score of NIHSS showed a downward trend with the change of time. The change of score of NIHSS on the factors of syndromes wind, heat, phlegm, deficiency of qi, The change of the score of Yin deficiency and Yang hyperactivity had an effect on each increase or decrease of the score of NIHSS, and the corresponding score of syndromes increased or decreased by 0.403, 0.224, 0.355, 0.376 and 0.157, respectively. Conclusion: the changes of NIHSS score in ischemic stroke are correlated with the scores of multiple syndromes at different time points, and the correlation degree is different.
【作者单位】：中国中医科学院中医基础理论研究所;中国人民大学统计学院;
【基金】：国家自然科学基金资助项目(30873460)-构建表征证候动态变化纵向结局评价指标的示范研究中国中医科学院自主选题项目(YZ-1533)-基于多重证据的中医临床诊疗策略及五运六气发生学研究
【分类号】：R277.7

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