二术清胃汤治疗慢性浅表性胃炎临床研究

发布时间：2018-08-11 21:25

【摘要】：目的:观察二术清胃汤治疗慢性浅表性胃炎脾胃湿热证的疗效及对血清中环氧化酶(cyclooxygenase,COX)-2和胃泌素(gastrin,Gas)的影响。方法:将慢性浅表性胃炎患者66例随机分为对照组(33例)和观察组(33例)。对照组给予施维舒胶囊,每次1粒,每天3次。观察组在对照组基础上予二术清胃汤治疗,每天1剂,常规水煎分2次温服。两组连续观察8周。比较两组症状体征评分、生活质量评分及临床疗效。检测血清中COX-2和Gas水平。结果:治疗后,观察组脘腹痞满、口干口苦、食少纳呆、身重困倦、恶心欲呕评分明显少于对照组,SF-36量表各指标评分显著高于对照组(P0.01)。观察组有效率为93.94%,明显高于对照组的69.70%(P0.05)。观察组治疗后血清中COX-2和Gas水平明显低于对照组(P0.01)。结论:二术清胃汤治疗慢性浅表性胃炎脾胃湿热证疗效显著,且可降低患者血清中COX-2和Gas水平。
[Abstract]:Objective: to observe the effect of Erzhu Qingwei decoction on chronic superficial gastritis with dampness and heat of spleen and stomach and its effect on serum cyclooxygenase oxidase (COX-2) and gastrin gas (gastrin Gas). Methods: 66 patients with chronic superficial gastritis were randomly divided into control group (33 cases) and observation group (33 cases). The control group was given 1 capsule of Schweisu three times a day. The observation group was treated with Erzhu Qingwei decoction on the basis of the control group. The two groups were observed for 8 weeks. The scores of symptoms and signs, quality of life and clinical efficacy were compared between the two groups. The serum levels of COX-2 and Gas were measured. Results: after treatment, the scores of epigastric fullness, dry mouth and bitter mouth, low food intake, heavy body weight, nausea and nausea in the observation group were significantly lower than those in the control group (P0.01). The effective rate of observation group was 93.94, which was significantly higher than that of control group (69.70%, P0.05). The levels of serum COX-2 and Gas in the observation group were significantly lower than those in the control group (P0.01). Conclusion: Erzhouqingwei decoction is effective in treating chronic superficial gastritis with dampness and heat of spleen and stomach, and can decrease the levels of COX-2 and Gas in serum.
【作者单位】：华东师范大学;
【基金】：上海市自然科学基金项目(13ZR1434300)
【分类号】：R259

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