祛湿活血汤治疗早期2型糖尿病性下肢动脉粥样硬化病变的临床研究

发布时间：2018-08-12 09:35

【摘要】：目的:从湿瘀论治早期2型糖尿病性下肢动脉粥样硬化病变,自拟祛湿活血汤,观察其临床疗效,探讨其作用机理,以期提高糖尿病性下肢动脉粥样硬化病变患者的生活质量。方法:将纳入的60例早期2型糖尿病性下肢动脉粥样硬化病变患者随机分为治疗组与对照组各30例。两组在基础治疗之上,对照组给予贝前列素钠片40μg/次,饭后口服,每日三次;治疗组在对照组之上加祛湿活血汤口服,早晚各200ml。共观察8周,主要观察指标为空腹血糖、餐后2小时血糖、糖化血红蛋白、总胆固醇、甘油三酯、纤维蛋白原、踝肱比、中医临床症状体征评分与双下肢动脉彩超评分。结果:临床观察显示:治疗组中医症候疗效总有效率83.33%,对照组中医症候疗效总有效率63.33%,两组比较有统计学差异(P0.05);两组均可改善血糖、血脂;治疗组在改善纤维蛋白原、踝肱比、中医临床症状体征评分与双下肢动脉彩超评分方面优于对照组(P0.05)。结论:祛湿活血汤可改善早期2型糖尿病性下肢动脉粥样硬化病变患者的血糖、血脂、纤维蛋白原、踝肱比、中医临床症状体征评分及双下肢动脉彩超评分,可对早期2型糖尿病性下肢动脉粥样硬化病变起到一定的防治作用,可提高患者的生活质量,推广意义良好。
[Abstract]:Objective: to treat early type 2 diabetic lower extremity atherosclerotic lesions from the viewpoint of dampness and blood stasis, to observe its clinical efficacy and to explore its mechanism, so as to improve the quality of life of patients with diabetic lower extremity atherosclerotic lesions. Methods: sixty patients with early type 2 diabetic atherosclerosis of lower extremity were randomly divided into treatment group (n = 30) and control group (n = 30). On the basis of basic treatment, the control group was given berprost sodium tablets 40 渭 g / time, orally three times a day after meals, and the treatment group was treated with Qushi Huoxue decoction on the top of the control group, 200ml in the morning and evening. The main indexes were fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, fibrinogen, ankle-brachial ratio, TCM clinical symptom and sign score and lower extremity artery color ultrasound score. Results: the clinical observation showed that the total effective rate of TCM syndrome in the treatment group was 83.33 and that in the control group was 63.33. There was a significant difference between the two groups (P0.05); both groups could improve blood glucose and blood lipid; the treatment group was improving fibrinogen, ankle-brachial ratio. TCM clinical symptoms and signs score and lower extremity artery color ultrasound score were better than the control group (P0.05). Conclusion: Qushi Huoxue decoction can improve blood sugar, blood lipid, fibrinogen, ankle-brachial ratio, clinical symptoms and signs of TCM and color Doppler ultrasound score of lower extremity artery in early type 2 diabetes mellitus patients with atherosclerosis of lower extremity. It can prevent and cure early type 2 diabetic atherosclerosis of lower extremity, improve the quality of life of the patients, and has a good significance in popularizing.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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