中草药治疗艾滋病随机对照临床试验的系统综述

发布时间：2018-08-12 20:01

【摘要】：目的评价中医药治疗艾滋病的疗效和安全性。方法纳入文献为中草药治疗艾滋病的随机对照临床试验。全面检索Pub Med、Cochrane对照试验注册中心及CNKI、维普、万方和CBM数据库(截至2013年4月)。自行设计资料提取表提取资料,采用Cochrane手册推荐的质量评价工具评价文献质量,应用RevMan5.1软件进行数据分析。结果 3个试验评价为低风险偏倚,其他均为高风险偏倚。艾灵颗粒与安慰剂比较(2个试验,120名受试者)结果显示:CD4细胞计数增加:MD95.47,95%CI:(41.52,149.41);健康相关生活质量评分:MD4.80,95%CI(2.63,6.96)。湘A2联合传统治疗与传统治疗联合安慰剂比较(2个试验,120名受试者):CD4细胞计数增加:MD42.92,95%CI:(4.92,80.86)。艾灵颗粒联合传统治疗与传统治疗联合安慰剂比较(5个试验,334名受试者),CD4细胞计数增加:MD60.82,95%CI:(27.00,94.65)。纳入试验无严重不良反应报告。结论部分中草药如艾灵颗粒等在艾滋病的治疗中表现出潜在优势疗效且无严重不良反应,但由于纳入试验的质量较低和中草药治疗的异质性较大,需要慎重解释结果并在将来的研究中加以验证。
[Abstract]:Objective to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of AIDS. Methods A randomized controlled clinical trial of Chinese herbal medicine for the treatment of AIDS was included in the literature. To search the Pub Medsite Cochrane controlled trial Registry and CNKI, Weip, Wanfang and CBM databases (as of April 2013). The data extraction table was designed by ourselves, and the quality evaluation tool recommended by Cochrane manual was used to evaluate the quality of literature, and the data was analyzed by RevMan5.1 software. Results three trials were evaluated as low risk bias, others were high risk bias. Compared with placebo (120 subjects in two trials), the results of Ai Ling granule showed that the CD4 cell count was increased by 10% MD95.47 and 95CI: (41.52149.41), and the health-related quality of life score was: MD4.809595 CI (2.63m6.96). Compared with traditional therapy and placebo, Xiang A2 combined with traditional therapy and placebo (120 subjects in two trials) showed an increase in the CD4 cell count of 10% MD42.92% 95 CI: (4.92% 80.86). Compared with traditional therapy combined with placebo, Ai Ling granule increased CD4 cell count in 5 subjects (n = 334) and increased CD _ 4 cell count in 10% MD60.82 ~ (95) CI: (27.00 卤94.65). No serious adverse reactions were reported in the trial. Conclusion some Chinese herbal medicines, such as Ai Ling granule, have potential advantages in the treatment of AIDS without serious adverse reactions, but due to the low quality of the trial and the heterogeneity of the Chinese herbal medicine treatment. The results need to be interpreted carefully and verified in future studies.
【作者单位】：北京中医药大学循证医学中心;
【基金】：中国全球基金艾滋病项目2012年支持社会组织参与艾滋病防治工作项目(No.CSO-2012-研51) 2013年教育部新世纪优秀人才支持计划项目(No.NCET-13-0694)
【分类号】：R259

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