基于近15年中医期刊文献对功能性消化不良的辨证用药特色探讨

发布时间：2018-08-13 12:13

【摘要】：目的通过对近15年来有关功能性消化不良的中医文献的研读,整理出中医治疗功能性消化不良的相关方剂,对其中包含的药物进行分析,以求总结出功能性消化不良中医治疗的用药特色,为当前祖国医学治疗功能性消化不良提供一定的思路借鉴。方法1研读文献,依照所制定的纳入及排除标准选择文献;2根据所选文献,整理出文献中所运用的有效方剂;3将每首方剂中的中药进行频次统计,建立图表数据库;4运用统计软件,将药物按照功能、四气五味、归经进行频次分析,分析其药物性味归经特点,用聚类分析、探索因子分析药物组合,发现其特点,组成新的方剂。结果1所选文献中共找出方剂111首,涉及中药130味,其中高于平均频次的药物共40味,分别为黄芪、芍药、甘草、生姜、大枣、柴胡、枳实、藿香、半夏、白术、茯苓、厚朴、陈皮、薏苡仁、豆蔻、乌药、黄芩、泽泻、党参、黄连、苏梗、丹参、沙参、延胡索、麦芽、山楂、神曲、香附、枳壳、木香、砂仁、郁金、佛手、山药、栀子、当归、石菖蒲、莱菔子、干姜、人参。2上述药物进行功能、四气五味、归经分析,药物功能以疏肝理气、健脾补虚、化湿和中类药物为最多,四气五味中温(22)、寒(9)、平(7)性药物和辛(21)、甘(15)、苦(19)类药物居多。药物归经中以脾经(33)、胃经(23)、肺经(17)、心经(10)、肝经(9)为多。3通过探索性因子分析及聚类分析最终得到3个药物的组方,分别是:F1:茯苓、白术、党参、木香、生姜、大枣。F2:白芍、柴胡、枳壳、香附、陈皮。F3:黄芩、干姜、人参、半夏、甘草、枳实、黄连、砂仁、厚朴。结论1现代中医治疗功能性消化不良重视温补,注重从调节脾胃气机升降着手用药;2现代中医治疗功能性消化不良与古代中医治疗时侧重“健脾补虚”的不同之处在于,更加注重疏肝理气,解郁补虚类药物的使用。
[Abstract]:Objective to study the Chinese medicine literature on functional dyspepsia in recent 15 years, and to sort out the relevant prescriptions for the treatment of functional dyspepsia, and to analyze the drugs contained therein. In order to sum up the characteristics of traditional Chinese medicine treatment of functional dyspepsia, for the current medical treatment of functional dyspepsia to provide some ideas for reference. Methods 1 study the literature, select the literature according to the standard of inclusion and exclusion. According to the selected literature, sort out the effective prescription used in the literature and make statistics on the frequency of the Chinese medicine in each prescription. A chart database was set up and statistical software was used to analyze the frequency of the medicine according to its function, four qi and five flavors, and to analyze the characteristic of its characteristic flavor and meridian. Cluster analysis was used to explore the combination of drugs by factor analysis, and its characteristics were found. Form a new prescription. Results 1A total of 111 prescriptions involving 130 kinds of traditional Chinese medicine were found in the selected literature, 40 of which were above the average frequency. They were astragalus, paeoniflorin, liquorice, ginger, jujube, Bupleurum, Fructus Aurantii, patchouli, Pinellia ternata, Atractylodes macrocephalae, Poria cocos, and Magnolia officinalis. Chenpi, Coix seed, nutmeg, black medicine, Radix Scutellariae, Radix Alismatis, Codonopsis, Coptidis, Pulp, Salvia miltiorrhiza, Radix Salviae, Rhizoma Corydalis, Malt, Hawthorn, Divine Comedy, Fraxinus, Fructus Aurantii, Amur, Tulip, Buddha's hand, yam, Gardenia, Angelica sinensis, Acorus calamus, semen Raphani, Rhizoma Raphani, Ginger, Ginseng .2 the above-mentioned drugs for function, four Qi five flavor, analysis of the meridian, drug function in soothing liver and regulating qi, invigorating spleen and tonifying deficiency, removing dampness and middle class drugs are the most. Most of the drugs were mild (22), cold (9), Ping (7) and Xin (21), Gan (15) and bitter (19). In the meridian of medicine, spleen meridian (33), stomach meridian (23), lung meridian (17), heart meridian (10), liver meridian (9) were used to obtain three drug formulations by exploratory factor analysis and cluster analysis. They were: Tuckahoe, Atractylodes macrocephala, Codonopsis pilosula, Amur, Ginger, Jujube. F2: Paeoniae Alba. Radix Bupleurum, Fructus Aurantii, Fructus Aurantii, Pericarpium F3: Scutellaria, Ginger, Ginseng, Pinellia ternata, liquorice, Fructus Aurantii, Coptis chinensis, Amomum, Magnolia officinalis. Conclusion (1) in the treatment of functional dyspepsia, modern Chinese medicine pays more attention to temperature supplement, and to regulating the rise and fall of spleen and stomach qi. 2 the difference between modern Chinese medicine treatment of functional dyspepsia and that of ancient Chinese medicine is that it is different from that of "strengthening spleen and reinforcing deficiency". Pay more attention to soothing the liver and regulating qi, relieving depression and tonifying the use of drugs.
【学位授予单位】：华北理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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