中药周期辨证疗法对再次行体外受精—胚胎移植（IVF-ET）患者妊娠结局的影响

发布时间：2018-08-14 09:12

【摘要】：目的探讨中药周期辨证疗法对经辅助生殖技术助孕失败后拟再次行试管助孕的患者受孕结局的影响。方法将拟再次行试管助孕的患者120例随机分为空白对照组(60例)和中药治疗组(60例)。空白对照组采用单纯辅助生殖技术,中药治疗组在Gn前给予中药治疗3个月经周期。最终入组者给予促性腺激素释放激素激动剂长方案,对比两组的试验指标。收集治疗前后两组的中医证候评分,观察治疗前后两组的肾虚肝郁血瘀证候的改善程度,然后将治疗后两组的HCG日子宫内膜厚度、获卵数、受精卵数、受精率进行比较,最后统计两组治疗后的临床妊娠率、早期流产率情况,将其进行对比。结果1.两组相比较,治疗前的各项指标均无明显差异(P0.05)。2.应用中药周期辨证疗法治疗后,比较两组的HCG日子宫内膜厚度、受精卵数、受精率、临床妊娠率,结果显示中药治疗组明显高于空白对照组,其统计学差异都有意义(P0.05);而对比两组的早期流产率,中药治疗组则明显低于空白对照组,差异有统计学意义(P0.05)。3.治疗后,将两组的中医证候进行对比,其中医证候评分及改善程度相比较都有统计学意义(P0.05)。结论本研究表明,中药周期辨证疗法可以增加经辅助生殖技术助孕失败后拟再次行试管助孕的患者的临床妊娠率,使用早期流产率降低。
[Abstract]:Objective to investigate the effect of Chinese traditional medicine (TCM) periodic syndrome differentiation therapy on the outcome of pregnancy after assisted reproductive technique failed. Methods 120 patients were randomly divided into blank control group (60 cases) and traditional Chinese medicine treatment group (60 cases). The blank control group was treated with simple assisted reproductive technique, and the traditional Chinese medicine group was treated with traditional Chinese medicine for 3 menstrual cycles before Gn. Finally, gonadotropin releasing hormone agonist long-term regimen was given to the patients, and the test indexes were compared between the two groups. The TCM syndromes scores of the two groups were collected before and after treatment, and the improvement degree of the syndrome of kidney deficiency, liver stagnation and blood stasis was observed before and after treatment, and then the thickness of endometrium, the number of eggs obtained and the fertilization rate of the two groups were compared after the treatment. Finally, the clinical pregnancy rate and early abortion rate were analyzed and compared between the two groups. Result 1. There was no significant difference between the two groups before treatment (P0.05). The thickness of endometrium, the number of fertilized eggs, fertilization rate and clinical pregnancy rate were compared between the two groups after the treatment of TCM periodic syndrome differentiation. The results showed that the treatment group was significantly higher than the blank control group. The statistical differences were significant (P0.05); compared with the early abortion rate of the two groups, the Chinese medicine treatment group was significantly lower than the blank control group, the difference was statistically significant (P0.05). 3. After treatment, the two groups of TCM syndromes were compared, the TCM syndromes score and the degree of improvement were statistically significant (P0.05). Conclusion this study shows that the Chinese medicine periodic syndrome differentiation therapy can increase the clinical pregnancy rate and reduce the early abortion rate of the patients who intend to use IVF after the assisted reproductive technology failed.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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