参术芩草汤治疗慢性萎缩性胃炎脾虚瘀热证的临床研究

发布时间：2018-08-14 14:12

【摘要】：目的：观察参术芩草汤对脾虚瘀热型慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的治疗作用,探讨参术芩草汤治疗CAG的理论基础和作用机制,总结导师单兆伟教授治疗CAG的经验,为中医药治疗慢性萎缩性胃炎提供新的思路和方法,以更好的服务于临床。方法：选取江苏省中医院单师门诊符合纳入标准的60例CAG患者,予以参术芩草汤治疗并随症加减,疗程为180天,疗程结束后,观察治疗前后症状积分、胃镜病理及Hp根除等变化情况,数据整理后进行统计学分析。结果：患者治疗后中医症状积分显著下降(P0.05),临床症状明显改善,其中治愈5例,显效22例,有效31例,无效2例,治愈率为8.3%,显效率为36.7%,总有效率为96.7%；患者治疗前后病理疗效比较,治疗后萎缩治愈率41.7%,总有效率76.7%；肠化治愈率26.9%,总有效率63.5%；异型增生治愈68.8%,总有效率81.3%；Hp感染根除率42.3%；治疗后萎缩、肠化、异型增生积分明显低于治疗前(P0.01),并且患者在服药过程中均无过敏反应及不良反应。结论：参术芩草汤对脾虚瘀热型慢性萎缩性胃炎有较好的疗效,能明显改善CAG患者的临床症状及胃镜病理,并且安全性较好,无不良反应。
[Abstract]:Objective: to observe the therapeutic effect of Shenzhouqingcao decoction on (chronic atrophic gastritis of chronic atrophic gastritis with spleen deficiency and stasis heat, to explore the theoretical basis and mechanism of Shenzhu Qincao decoction in treating CAG, and to summarize the experience of professor Dan Zhaowei in treating CAG. To provide new ideas and methods for the treatment of chronic atrophic gastritis with traditional Chinese medicine, in order to better serve the clinical. Methods: sixty patients with CAG who met the inclusion criteria in the outpatient clinic of Jiangsu traditional Chinese Medicine Hospital were selected and treated with Shenzhu Qincao decoction. The course of treatment was 180 days. After the course of treatment, the symptom scores were observed before and after the treatment. The changes of gastroscopy pathology and HP eradication were analyzed statistically. Results: after treatment, the scores of TCM symptoms decreased significantly (P0.05), and the clinical symptoms were obviously improved. Among them, 5 cases were cured, 22 cases were effective, 31 cases were effective, 2 cases were ineffective, the cure rate was 8.3%, the effective rate was 36.7%, and the total effective rate was 96.7%. After treatment, the cure rate of atrophy was 41.7 and the total effective rate was 76.70.The cure rate of intestinal metaplasia was 26.9 and the total effective rate was 63.50.The cure rate of dysplasia was 68.8%, the total effective rate was 81.3%, and the eradication rate of HP infection was 42.3%. The score of dysplasia was significantly lower than that before treatment (P0.01). Conclusion: Shenzhouqingcao decoction has better curative effect on chronic atrophic gastritis of spleen deficiency and stasis heat type, can obviously improve the clinical symptom and gastroscope pathology of CAG patients, and has good safety and no adverse reaction.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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