大黄灌肠对重症急性胰腺炎患者血清高迁移率族蛋白B1、PCT的临床研究

发布时间：2018-08-17 14:13

【摘要】：目的:观察大黄灌肠对重症急性胰腺炎(severe acute pancreatitis,SAP)患者血清高迁移率族蛋白B1(High mobility group B1,HMGB-1)与降钙素原(Procalcitonin PCT)的影响。方法:收集重症胰腺炎患者60例,随机分为大黄治疗观察组(30例)和常规治疗对照组(30例),分别在入院后第1、3、5天动态监测各组患者的HMGB1与PCT浓度变化。结果:治疗前两组患者HMGB-1、PCT水平差异均无统计学意义;治疗后5天,观察组患者HMGB-1、PCT水平较治疗前显著降低。Δ3-1HMGB1(第3天与第1天的HMGB1差值)与(acute physiology and chronic health evaluation system APACHEⅡ)评分呈明显负相关,与PCT呈明显正相关。结论:大黄通过有效抑制重症急性胰腺炎患者晚期炎症因子HMGB-1表达量,进一步能改善重症胰腺炎的症状和转归,为其治疗重症急性胰腺炎提供新的作用机制。
[Abstract]:Objective: to observe the effect of rhubarb enema on serum high mobility group protein B1 (High mobility group B1 HMGB-1 and procalcitonin (Procalcitonin PCT) in patients with severe acute pancreatitis (severe acute pancretis SAP). Methods: sixty patients with severe pancreatitis were randomly divided into two groups: rhubarb treatment group (n = 30) and routine treatment group (n = 30). The concentrations of HMGB1 and PCT in each group were dynamically monitored on the 3rd day after admission. Results: there was no significant difference in HMGB-1 PCT levels between the two groups before and 5 days after treatment. In the observation group, HMGB-1 was significantly lower than that before treatment, 螖 3-1HMGB1 (HMGB1 difference between day 3 and day 1) was significantly negatively correlated with (acute physiology and chronic health evaluation system APACHE 鈪，

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