健脾固肾活血汤治疗早期糖尿病肾病的临床观察

发布时间：2018-08-17 14:30

【摘要】：目的:本课题旨在用健脾固肾活血汤治疗早期糖尿病肾病患者,通过观察患者的临床症状积分、主要症状改善以及糖化血红蛋白、胱抑素-c、β2-MG、NAG、24h U-TP、m ALB/Cr等实验室指标的变化,探讨健脾固肾活血汤治疗早期糖尿病肾病的疗效和机理。方法:选出符合要求的早期糖尿病肾病患者60例,随机分为对照组和治疗组,每组患者均为30例,两组均用常规西医治疗,对照组(30例)加贝那普利片,治疗组给予健脾固肾活血汤中药制剂口服。两组观察时间相同,均为12周。通过收集并对比分析每位患者在治疗前、治疗后中医临床症状积分、主要症状改善情况以及实验室检测指标变化,并应用SPSS19.0统计软件对收集的数据进行统计分析,以了解健脾固肾活血汤对早期糖尿病肾病患者的疗效。结果:研究结果显示,总体疗效方面:治疗组明显优于对照组(治疗组总有效率93.3%,对照组的总有效率63.3%)。脾肾两虚,瘀血阻滞症状积分方面,差异显著(P0.05)实验室指标方面:两组治疗前后糖化血红蛋白、胱抑素-c、β2-MG、NAG、24h U-TP、m ALB/Cr等均有下降,治疗组的上述实验室指标下降的更为明显(P0.05),治疗组优于对照组。结论:在基础治疗上加服健脾固肾活血汤能明显提高早期糖尿病肾病患者(脾肾两虚瘀血内阻证)的临床疗效,能降低患者尿蛋白含量,可改善糖化血红蛋白、胱抑素-c、β2-MG、24h U-TP、NAG、m ALB/Cr等实验室指标。
[Abstract]:Objective: to treat early diabetic nephropathy patients with Jianpi Gushen Huoxue decoction, and to observe the clinical symptom score, main symptom improvement and the changes of glycosylated hemoglobin, cystatin, 尾 2-MGN NAGN 24 h U-TPm ALB/Cr, etc. To explore the therapeutic effect and mechanism of Jianpi Gushen Huoxue decoction in the treatment of early diabetic nephropathy. Methods: sixty patients with early diabetic nephropathy were randomly divided into control group and treatment group. 30 patients in each group were treated with routine western medicine, and 30 patients in control group were treated with Gabinapril tablets. The treatment group was given Jianpi-gu-Shen Huoxue decoction oral Chinese medicine. The observation time was the same in both groups (12 weeks). By collecting and comparing the scores of clinical symptoms, the improvement of main symptoms and the changes of laboratory indicators of each patient before and after treatment, the data collected were statistically analyzed by SPSS19.0 software. To understand the effect of Jianpi Gushen Huoxue decoction on early diabetic nephropathy. Results: the results showed that the total efficacy of the treatment group was significantly better than that of the control group (the total effective rate of the treatment group was 93.3%, the total effective rate of the control group was 63.3%). There were significant differences in the scores of spleen and kidney deficiency and blood stasis (P0.05) between the two groups: before and after treatment, glycosylated hemoglobin, cystatin -c, 尾 2-MGG NAGN 24 h U-TPN ALB/Cr were decreased in the two groups. The above laboratory indexes in the treatment group decreased more significantly (P0.05), and the treatment group was better than the control group. Conclusion: taking Jianpi Gushen Huoxue decoction on basic treatment can obviously improve the clinical effect of early diabetic nephropathy (spleen and kidney deficiency and blood stasis internal obstruction syndrome), can reduce the urine protein content of patients, and can improve glycosylated hemoglobin. Cystatin-c, 尾 2-MGN 24 h U-TPN nag m ALB/Cr.
【学位授予单位】：陕西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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