针刺对急性脑梗死患者血清IL-10、IL-18及神经功能缺损影响的临床研究

发布时间：2018-08-22 12:28

【摘要】：目的:观察针刺对急性脑梗死患者血清IL-10、IL-18水平变化以及神经功能缺损情况的影响,探讨针刺对急性脑梗死的治疗作用及其机制。方法:本课题采用随机对照试验,对福建医科大学附属协和医院神经内科的69例合格的急性脑梗死住院患者,随机分成对照组和试验组。两组均接受神经内科常规药物治疗,试验组加上针刺治疗,针刺穴位选择头针的顶颞前斜线和体针的肩前、尺泽、内关、合谷,髀关、伏兔、足三里、三阴交。干预时间为每天1次,每次60分钟,连续观察14天。疗效评价主要指标为血清白细胞介素10、白细胞介素18的浓度,次要指标为神经功能缺损评分(NIHSS),于治疗前后分别对两组进行观察、评定。结果数据采用SPSS软件统计处理。结果:1.治疗后,试验组和对照组血清IL-10浓度的均较治疗前有所提高,与治疗前相比,均具有显著性统计学差异(P0.01);且试验组优于对照组(P0.05)。2.治疗后,试验组和对照组血清IL-18浓度的均较治疗前有所降低,与治疗前相比,均具有显著性统计学差异(P0.01);且试验组优于对照组(P0.05)。3.治疗后,试验组和对照组NIHSS评分均较治疗前有所降低,与治疗前相比,均具有显著性统计学差异(P0.01);但治疗后两组评分无明显统计学差异(P0.05)。结论:1.两种治疗方案均能不同程度地影响脑梗死后血清IL-10、IL-18水平。2.在脑梗死急性期,相比内科药物治疗,针刺结合内科药物治疗对炎症方面具有更明显改善,而在神经功能恢复方面无明显差异。
[Abstract]:Objective: to observe the effect of acupuncture on the changes of serum IL-10 IL-18 level and neurological deficit in patients with acute cerebral infarction, and to explore the therapeutic effect and mechanism of acupuncture on acute cerebral infarction. Methods: a randomized controlled trial was conducted in 69 inpatients with acute cerebral infarction in Department of Neurology, Union Hospital, Fujian Medical University, and were randomly divided into two groups: control group and experimental group. Both groups were treated with routine medicine in neurology. The experimental group was treated with acupuncture. Acupuncture points were selected for scalp acupuncture in front of the parietal and temporal oblique lines and in front of the shoulders of body acupuncture, ulnazawa, Neiguan, Hegu, Biguan, Fu rabbit, Zusanli, Sanyinjiao. The intervention time was 1 time per day, 60 minutes each time, continuously observed for 14 days. The main outcome measures were the concentration of serum interleukin 10 and interleukin 18. The secondary index was nerve function defect score (NIHSS),). The two groups were observed and evaluated before and after treatment. Results the data were processed by SPSS software. The result is 1: 1. After treatment, the concentration of serum IL-10 in the experimental group and control group were higher than before treatment, compared with before treatment, there was significant statistical difference (P0.01), and the test group was better than the control group (P0.05). 2. After treatment, the concentration of serum IL-18 in the experimental group and control group were lower than before treatment, compared with before treatment, there was significant statistical difference (P0.01), and the test group was better than the control group (P0.05). 3. After treatment, the NIHSS scores of the experimental group and the control group were lower than those before treatment, and there was significant statistical difference between the two groups (P0.01), but there was no significant difference between the two groups after treatment (P0.05). Conclusion 1. The two treatment regimens can affect the level of IL-10 and IL-18 in different degree after cerebral infarction. In the acute phase of cerebral infarction, acupuncture combined with internal medicine had more obvious improvement on inflammation than that of internal medicine, but there was no significant difference in the recovery of nerve function.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R246.6

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