药线植入疗法治疗结肠慢传输便秘的临床研究

发布时间：2018-08-23 12:31

【摘要】：目的:观察药线植入疗法治疗结肠慢传输便秘的临床研究。方法:将92例结肠慢传输便秘患者,随机分为药线治疗组、羊肠线对照组、口服枸缘酸莫沙比利对照组。其中药线治疗组31例患者;羊肠线对照组30例患者,口服枸橼酸莫沙必利组29例患者。药线治疗组和羊肠线对照组均治疗1次,口服枸橼酸莫沙必利组服药2周。观察三组患者分别在治疗前、第2周、第4周和第6周的各症状评分及总有效率。结果:1.第2周,药线治疗组与羊肠线对照组和枸橼酸莫沙必利对照组三组患者各症状较治疗前均有所改善,药线治疗组总有效率为96.8%,羊肠线对照组总有效率为90.0%,口服枸缘酸莫沙比利对照组总有效率为86.2%,P0.05,无统计学意义,三组患者第2周疗效相互之间无明显差异。2.第4周,治疗组总有效率为96.8%,羊肠线对照组总有效率为90.0%,停药两周后枸缘酸莫沙比利对照组第4周总有效率为37.9%,药线治疗组与羊肠线对照组相比较,P0.05,无统计学意义;药线治疗组与口服枸缘酸莫沙比利对照组、羊肠线对照组与口服枸缘酸莫沙比利对照组相比较,P0.01有统计学意义,提示药线治疗组与羊肠线对照组第4周疗效比较无明显差异,药线治疗组和羊肠线对照组第4周的总有效率明显优于口服枸缘酸莫沙比利对照组。3.第6周,治疗组总有效率为96.8%,羊肠线对照组总有效率90.0%,停药四周后的口服药物对照组第6周总有效率为27.6%,药线治疗组与羊肠线对照组相比较,P0.05,药线治疗组与口服药物对照组、羊肠线对照组与口服药物对照组比较,均为P0.01,提示第6周治疗组与羊肠线对照组总有效率无明显差异,治疗组与羊肠线对照组总有效率明显优于口服药物对照组。4.症状评分方面,排便费力度、排便时间症状评分,治疗组在第2周、第4周、第6周与羊肠线对照组及枸缘酸莫沙比利对照组相比,均P0.05,有统计学意义,提示治疗组在第2周、第4周、第6周排便费力度、排便时间上疗效优于羊场线对照组及枸缘酸莫沙比利对照组。余症状评分方面,药线治疗组与羊肠线对照组在第2周、第4周、第6周中,均为P0.05,无统计学意义。结论:药线植入疗法治疗结肠慢传输便秘疗效显著,远期疗效评价,与羊肠线对照组相比无明显差异,与口服药物对照组相比差异明显。症状改善方面,在排便费力度和排便时间上,药线植入疗法优于羊肠线对照组。
[Abstract]:Objective: to observe the clinical study of colonic slow transit constipation treated by drug line implantation. Methods: 92 patients with colonic slow transit constipation were randomly divided into drug therapy group, sheep intestinal line control group and oral moxapride citrate control group. There were 31 patients in the drug line group, 30 patients in the intestinal line control group and 29 patients in the oral mosapride citrate group. The drug line treatment group and the intestinal line control group were treated once, oral mosapride citrate group for 2 weeks. The symptom scores and the total effective rate of the three groups were observed before, 2, 4 and 6 weeks after treatment. The result is 1: 1. In the second week, the symptoms of the three groups were improved compared with those of the control group, the control group and the mosapride citrate group. The total effective rate of the drug line treatment group was 96.8um, the total effective rate of the sheep intestine line control group was 90.0 and the total effective rate of the oral moxapride citrate group was 86.2p 0.05. There was no significant difference between the three groups at the 2nd week. At the 4th week, the total effective rate of the treatment group was 96.8g, the total effective rate of the control group was 90.0 and the total effective rate of moxapride citrate was 37.9% in the control group two weeks after the withdrawal of the drug. There was no significant difference between the treatment group and the control group (P 0.05). There was significant difference between the drug line group and the oral moxapride citrate control group, the sheep intestinal line control group and the oral moxapride citrate control group, which indicated that there was no significant difference between the drug line treatment group and the sheep intestinal line control group at the 4th week. The total effective rate of the drug line therapy group and the sheep intestinal line control group was significantly better than that of the oral moxapride citrate group. 3. At the 6th week, the total effective rate in the treatment group was 96.8, the total effective rate in the control group was 90.0, the total effective rate in the oral drug control group after four weeks was 27.60.The total effective rate in the drug line treatment group was higher than that in the sheep intestine line control group, and that in the drug line treatment group was higher than that in the sheep intestinal line control group, and the drug line treatment group and the oral drug control group. Compared with the oral drug control group, the total effective rate of the treatment group and the control group was not significantly different at the 6th week, and the total effective rate of the treatment group and the control group was significantly better than that of the oral drug control group. Symptom score, defecation fee, defecation time symptom score, the treatment group in the 2nd week, 4th week, 6th week, compared with the control group of intestinal line and moxapride citrate control group, all have statistical significance, suggesting that the treatment group in the second week, In the 4th week, the 6th week, the defecation cost and the defecation time were better than those of the sheep farm line control group and the moxapride citrate control group. The scores of residual symptoms in the treatment group and the control group were all P0.05 in the 2nd week, 4th week and 6th week, with no statistical significance. Conclusion: the treatment of colonic slow transit constipation with drug thread implantation has a significant effect. The long-term curative effect evaluation has no significant difference compared with the control group of sheep's intestinal line, and the difference is obvious compared with the oral drug control group. In the improvement of symptoms, the drug line implantation therapy was superior to the control group in defecation cost and defecation time.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35

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