鹿角壮骨胶囊对绝经后骨质疏松症患者生殖内分泌激素及骨代谢的影响

发布时间：2018-08-23 14:22

【摘要】：目的:探讨鹿角壮骨胶囊对绝经后骨质疏松症患者生殖内分泌激素及骨代谢的影响。方法:120例绝经后骨质疏松症患者采用随机数字表法分为对照组(59例)和观察组(61例)。对照组患者口服碳酸钙D3片,每次1片,tid和阿法骨化醇胶囊,每次0.50μg,tid;观察组患者在对照组基础上加服鹿角壮骨胶囊,每次1.35 g,tid。两组均以3个月为1个疗程,治疗2个疗程。分别于治疗前和治疗3、6个月时,比较两组患者腰椎正位(L1~L4)和股骨颈骨密度(BMD)、血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_2)、睾酮(T)、骨钙素(BGP)、降钙素(CT)和甲状旁腺激素(PTH)含量的变化及不良反应发生情况。结果:观察组和对照组分别有3、2例患者脱落。治疗前,两组患者各项指标比较,差异均无统计学意义(P0.05);治疗3个月时,观察组患者血清FSH、E_2、BGP、CT和PTH含量较治疗前显著升高,且显著高于对照组,差异有统计学意义(P0.05);治疗6个月时,两组患者腰椎正位(L1~L4)和股骨颈BMD及血清FSH、E_2、BGP、CT、PTH含量均较治疗前和(或)治疗3个月时显著升高,且观察组显著高于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:鹿角壮骨胶囊对绝经后骨质疏松症患者生殖内分泌激素具有一定的调节作用,且可提高患者BMD,减少骨转化。
[Abstract]:Objective: to investigate the effect of Lujiao Zhuanggu capsule on reproductive endocrine hormone and bone metabolism in postmenopausal osteoporosis patients. Methods 120 postmenopausal osteoporosis patients were randomly divided into control group (59 cases) and observation group (61 cases). The patients in the control group received oral calcium carbonate D3 tablets, 1 tablet tid and 1 tablet of Alfarin capsule, 0.50 渭 g / time, and the patients in the observation group were treated with Lujiao Zhuanggu capsule (1.35 g / time) on the basis of the control group. The two groups were treated with 3 months as a course of treatment and 2 courses of treatment. Before treatment and at 3 and 6 months after treatment, The changes of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone (T), osteocalcin (BGP), (BGP), calcitonin (CT) and parathyroid hormone (PTH) in patients with lumbar vertebrae positive position (L1~L4) and femoral neck bone mineral density (BMD),) were compared. Results: 32 patients in the observation group and 2 in the control group dropped off. Before treatment, there was no significant difference between the two groups (P0.05). After 3 months of treatment, the levels of serum FSHE 2BGP CT and PTH in the observation group were significantly higher than those before treatment, and significantly higher than those in the control group. After 6 months of treatment, the levels of L1~L4, BMD of femoral neck and serum FSHE2BGPCT-CTH in the two groups were significantly higher than those before treatment and / or at 3 months after treatment, and the levels in the observation group were significantly higher than those in the control group. The difference was statistically significant (P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion: Lujiao Zhuanggu capsule can regulate reproductive endocrine hormone in postmenopausal osteoporosis patients, and can increase BMDand reduce bone transformation.
【作者单位】：贵州省黔南布依族苗族自治州中医医院骨伤科;
【基金】：贵州省省长研究课题计划
【分类号】：R259

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