非小细胞肺癌患者中医体质证型与EGFR基因的相关性研究

发布时间：2018-08-25 18:46

【摘要】：目的探讨非小细胞肺癌(NSCLC)患者中医体质、证型与EGFR的相关性。方法调查分析512例NSCLC患者中医体质、证型、EGFR基因突变状态,探析中医体质、证型及EGFR基因突变的相关性。结果 NSCLC患者常见体质为气虚质、痰湿质、阴虚质、气郁质。中医证型以脾虚痰湿证,气阴两虚证为主。相关性分析结果表明,NSCLC患者中医体质与证型密切相关。512例患者中EGFR总突变率为48.4%,痰湿质与湿热质患者突变率在9种体质中突变率较高,脾虚痰湿证患者在不同中医证型中突变率最高,而阴虚痰热证、肺郁痰瘀证及气阴两虚证中突变率无明显差异。结论 NSCLC患者中医体质与证型密切相关,EGFR基因在不同体质及中医证型中突变率差异明显,研究NSCLC患者不同中医体质、证型与EGFR基因的相关性对提高NSCLC中医诊疗水平具有一定价值。
[Abstract]:Objective To explore the correlation between constitution, syndrome types and EGFR in patients with non-small cell lung cancer (NSCLC).Methods The constitution, syndrome types and mutation status of EGFR gene in 512 patients with NSCLC were investigated and analyzed. The correlation analysis showed that the total mutation rate of EGFR was 48.4% in 512 patients, the mutation rate of phlegm-dampness and dampness-heat was higher in 9 constitutions, and the mutation rate of spleen-deficiency and phlegm-dampness syndrome was the highest in different TCM syndrome types, while the mutation rate of Yin-deficiency and phlegm-dampness syndrome was the highest. There was no significant difference in mutation rate among heat syndrome, lung stagnation, phlegm stasis syndrome and deficiency of both qi and Yin syndrome.Conclusion The constitution of traditional Chinese medicine in NSCLC patients is closely related to syndrome types.The mutation rate of EGFR gene in different constitutions and syndromes of traditional Chinese medicine is significantly different.To study different constitutions of traditional Chinese medicine in NSCLC patients,the correlation between syndrome types and EGFR gene can improve the level of diagnosis and treatment of NSCLC in traditional Chinese medicine. Value.
【作者单位】：郑州大学附属肿瘤医院河南省肿瘤医院;
【基金】：国家自然科学基金面上项目(No.81473638)
【分类号】：R273

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