尿毒康合剂保留灌肠治疗慢性肾衰竭临床研究

发布时间：2018-08-25 19:48

【摘要】：目的观察尿毒康合剂治疗慢性肾衰的临床疗效,并探讨其机理。方法采用随机对照方法将60例慢性肾衰患者随机分为治疗组30例(常规治疗+尿毒康合剂灌肠)和对照组30例(常规治疗)。观察治疗前后两组临床症状及实验室指标水平变化。结果 (1)两组治疗后,血尿素氮(BUN)、血肌酐(Scr)水平均有下降,分别同各组治疗前比较有统计学意义(P0.05)。治疗组治疗后肌酐清除率(CCr)上升,治疗前后比较有统计学意义(P0.05);对照组治疗后CCr虽有上升,但同治疗前比较没有统计学意义(P0.05)。其中两组治疗后的Scr、BUN和CCr水平比较,差异有统计学意义(P0.05)。两组治疗后较治疗前血红蛋白(HGB)水平上升,差异均有统计学意义(P0.05);治疗后的两组比较无统计学意义。(2)两组治疗后较治疗前疲倦乏力、纳差呕恶、腰膝酸软、水肿临床症状积分均有下降,差异有统计学意义(P0.05);其中两组治疗后纳差呕恶、水肿临床症状积分比较,治疗组较对照组下降更明显,差异有统计学意义(P0.05);结论尿毒康合剂保留灌肠不仅能有效改善慢性肾衰患者的临床症状,同时还可改善患者实验室指标的水平。
[Abstract]:Objective to observe the clinical effect of Niaodukang mixture on chronic renal failure and explore its mechanism. Methods 60 patients with chronic renal failure were randomly divided into treatment group (30 cases) and control group (30 cases). The changes of clinical symptoms and laboratory indexes were observed before and after treatment. Results (1) after treatment, blood urea nitrogen (BUN),) and serum creatinine (Scr) levels decreased in both groups, which were statistically significant compared with those before treatment (P0.05). The creatinine clearance rate (CCr) increased after treatment in the treatment group (P0.05); in the control group, CCr increased after treatment, but there was no significant difference between before and after treatment (P0.05). There were significant differences in Scr,BUN and CCr levels between the two groups after treatment (P0.05). The level of hemoglobin (HGB) in the two groups increased after treatment (P0.05), but there was no significant difference between the two groups after treatment. (2) after treatment, the two groups were tired and tired, poor in anorexia, weak in waist and knee, and weak in waist and knee. The scores of clinical symptoms of edema were all decreased, the difference was statistically significant (P0.05); the scores of anorexia and nausea were more obvious in the treatment group than in the control group, and the scores of the clinical symptoms of edema in the treatment group were significantly lower than those in the control group. Conclusion the retention enema of Niaodukang mixture can not only effectively improve the clinical symptoms of patients with chronic renal failure, but also improve the level of laboratory indicators.
【作者单位】：广州中医药大学第四临床医学院;广州中医药大学附属中山中医院;
【基金】：国家临床重点专科基金(财社[2013]239号)
【分类号】：R277.5

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